喹喔啉-2(1H)-酮与惰性烷基和芳基氯化物的无金属直接C3-H烷基化和芳基化反应
Metal-Free Direct C3-H Alkylation and Arylation of Quinoxalin-2(1H)-Ones with Inert Alkyl and Aryl Chlorides.
作者信息
Tripathy Alisha Rani, Mishra Ashutosh, Singh Vesaj, Yatham Veera Reddy
机构信息
School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram (IISER-TVM), 695551, India.
出版信息
Chemistry. 2023 Aug 21;29(47):e202300774. doi: 10.1002/chem.202300774. Epub 2023 Jul 24.
In the present manuscript, we reported the first visible-light-enabled direct C3-H alkylation/arylation of quinoxalin-2(1H)-ones with unactivated alkyl/aryl chlorides under metal-free conditions. A wide range of unactivated alkyl and aryl chlorides containing different functionalities are coupled with a variety of quinoxalin-2(1H)-one derivatives under mild reaction conditions to afford the C3-alkyl/aryl substituted quinoxalin-2(1H)-ones in moderate to good yields.
在本论文中，我们报道了首例在无金属条件下，喹喔啉-2(1H)-酮与未活化的烷基/芳基氯化物实现的可见光促进直接C3-H烷基化/芳基化反应。多种含有不同官能团的未活化烷基和芳基氯化物，在温和的反应条件下与多种喹喔啉-2(1H)-酮衍生物发生偶联反应，以中等至良好的产率得到C3-烷基/芳基取代的喹喔啉-2(1H)-酮。
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