Tripathy Alisha Rani, Mishra Ashutosh, Singh Vesaj, Yatham Veera Reddy
School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram (IISER-TVM), 695551, India.
Chemistry. 2023 Aug 21;29(47):e202300774. doi: 10.1002/chem.202300774. Epub 2023 Jul 24.
In the present manuscript, we reported the first visible-light-enabled direct C3-H alkylation/arylation of quinoxalin-2(1H)-ones with unactivated alkyl/aryl chlorides under metal-free conditions. A wide range of unactivated alkyl and aryl chlorides containing different functionalities are coupled with a variety of quinoxalin-2(1H)-one derivatives under mild reaction conditions to afford the C3-alkyl/aryl substituted quinoxalin-2(1H)-ones in moderate to good yields.
在本论文中，我们报道了首例在无金属条件下，喹喔啉-2(1H)-酮与未活化的烷基/芳基氯化物实现的可见光促进直接C3-H烷基化/芳基化反应。多种含有不同官能团的未活化烷基和芳基氯化物，在温和的反应条件下与多种喹喔啉-2(1H)-酮衍生物发生偶联反应，以中等至良好的产率得到C3-烷基/芳基取代的喹喔啉-2(1H)-酮。
