Department of Biotechnology, Berhampur University, Berhampur, India.
Department of Biotechnology, St Aloysius College, Jabalpur, India.
Lupus. 2023 Jul;32(8):983-992. doi: 10.1177/09612033231182202. Epub 2023 Jun 7.
Systemic lupus erythematosus (SLE) is an autoimmune disorder with a wide range of clinical manifestations, including neurological issues in about 25%-75% of cases. Among the neurological involvement cases, most cases show migraine. However, the prevalence of migraine varied worldwide, and in some studies, a higher incidence of migraine in SLE cases was reported compared to healthy controls. In the present study, we adopted a meta-analysis approach to find out the prevalence of migraine in SLE patients worldwide and investigate whether migraine frequency is more prevalent in SLE patients than controls.
Various literature databases such as Scopus, PubMed, Science Direct, and Google Scholar were screened for eligible studies. The last search was performed on January 21, 2023. Publication biases were accessed by Egger's regression analysis and funnel plots. Cochrane Q statistics and I values explored the presence or absence of heterogeneity. All statistical analysis of meta-analysis was performed in comprehensive meta-analysis software v3.
Based on predefined inclusion and exclusion criteria, 17 reports comprising 2901 SLE patients and 575 healthy controls were considered in the present study. The meta-analysis revealed the prevalence of migraine to be 34.8%. Furthermore, migraine was more prevalent in SLE patients than healthy controls (OR: 1.964, = 0.000, 95% CI = 1.512-2.550). Similar trends were also observed while considering another 10 independent reports those were not disclosed about the migraine diagnosis criteria (number of reports: 27, SLE: 3473, HC: 741, prevalence: 33.5%, SLE vs HC: OR = 2.107, = 0.000, 95% CI = 1.672-2.655). Subgroup analysis demonstrated that SLE patients from South America had a higher prevalence of migraine (56.2%).
About one-third of SLE patients experience migraine worldwide. The prevalence of migraine is more frequent in SLE patients than the healthy controls.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，临床表现广泛，约 25%-75%的病例存在神经问题。在神经受累病例中，大多数表现为偏头痛。然而，偏头痛的全球患病率存在差异，在一些研究中，SLE 病例的偏头痛发病率高于健康对照组。在本研究中，我们采用荟萃分析方法来确定全球 SLE 患者偏头痛的患病率，并探讨偏头痛频率是否高于对照组。
筛选了 Scopus、PubMed、Science Direct 和 Google Scholar 等各种文献数据库，以获取合格的研究。最后一次搜索于 2023 年 1 月 21 日进行。采用 Egger 回归分析和漏斗图评估发表偏倚。Cochrane Q 统计量和 I 值评估异质性的存在或缺失。所有荟萃分析的统计分析均在 Comprehensive Meta-Analysis 软件 v3 中进行。
根据预设的纳入和排除标准，本研究纳入了 17 份报告，共 2901 例 SLE 患者和 575 例健康对照者。荟萃分析显示，偏头痛的患病率为 34.8%。此外，偏头痛在 SLE 患者中比健康对照组更为常见（OR：1.964， = 0.000，95%CI = 1.512-2.550）。在考虑另外 10 份未公开偏头痛诊断标准的独立报告时（报告数量：27，SLE：3473，HC：741，患病率：33.5%，SLE 与 HC：OR = 2.107， = 0.000，95%CI = 1.672-2.655）时，也观察到了类似的趋势。亚组分析表明，来自南美洲的 SLE 患者偏头痛患病率较高（56.2%）。
全球约有三分之一的 SLE 患者患有偏头痛。偏头痛在 SLE 患者中的发生率高于健康对照组。
