University Department of Zoology, Kolhan University, Chaibasa, Jharkhand, 833202, India.
ImmGen EvSys Laboratory, Department of Biotechnology, Berhampur University, Bhanja Bihar, Berhampur, Odisha, 760007, India.
Biochem Genet. 2024 Oct;62(5):3350-3366. doi: 10.1007/s10528-023-10600-9. Epub 2023 Dec 16.
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by autoantibody production and organ involvement. The role of toll-like receptor-7 in SLE is well established. Although genetic variations in the TLR-7 gene have been associated with an increased risk of developing SLE, the findings are not consistent. We performed a meta-analysis of previously published articles on four important single nucleotide polymorphisms in the TLR-7 gene (rs3853839, rs179008, rs179019, and rs179010) to reach a valid conclusion. Various literature databases, including PubMed, Science Direct, and Scopus, were scoured for eligible reports until May 10, 2023. GPower software v.3 was used to assess the power of individual reports included in the meta-analysis. Comprehensive Meta-analysis v3 software was used to perform all statistics. The publication biases in each genetic comparison model were investigated using funnel plots and Egger's regression test. To test heterogeneity, Cochrane Q statistics, probability value and I were used. Considering the predefined inclusion and exclusion criteria, the current study included a total of 10 eligible studies that included 15,472 SLE cases and 16,721 healthy controls. The meta-analysis revealed a significant association between TLR7 polymorphisms (rs179019 and rs179010) and susceptibility to SLE development. Other TLR7 polymorphisms (rs3853839 and rs179008), on the other hand, showed no significant association. Furthermore, the trial sequential analysis identified the need for additional case control studies for TLR-7 polymorphisms (rs3853839, rs179008, and rs179019) other than the rs179010 polymorphism. TLR7 variants for rs179010 and rs179019 are risk factor for the development of SLE. Further investigations are required to reach a valid conclusion.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征是自身抗体的产生和器官受累。Toll 样受体-7 在 SLE 中的作用已得到充分证实。尽管 TLR-7 基因的遗传变异与 SLE 发病风险增加有关，但这些发现并不一致。我们对 TLR-7 基因中四个重要的单核苷酸多态性（rs3853839、rs179008、rs179019 和 rs179010）的已发表文章进行了荟萃分析，以得出有效的结论。我们检索了包括 PubMed、Science Direct 和 Scopus 在内的各种文献数据库，直到 2023 年 5 月 10 日，以获取符合条件的报告。使用 GPower 软件 v.3 评估荟萃分析中包含的单个报告的效力。使用 Comprehensive Meta-analysis v3 软件进行所有统计。使用漏斗图和 Egger 回归检验研究每个遗传比较模型中的发表偏倚。使用 Cochran Q 统计量、概率值和 I 检验异质性。根据预先设定的纳入和排除标准，本研究共纳入了 10 项符合条件的研究，共纳入了 15472 例 SLE 病例和 16721 例健康对照。荟萃分析显示 TLR7 多态性（rs179019 和 rs179010）与 SLE 发病易感性显著相关。另一方面，其他 TLR7 多态性（rs3853839 和 rs179008）则无显著相关性。此外，试验序贯分析确定需要对 TLR-7 多态性（rs3853839、rs179008 和 rs179019）进行更多的病例对照研究，而不仅仅是 rs179010 多态性。TLR7 变体 rs179010 和 rs179019 是 SLE 发展的危险因素。需要进一步的研究来得出有效的结论。
