Li Rui, Han Jing, Shao Guoliang, Liu Changyue, Li Shuo, Wang Mengmeng, Yang Dianhui
Acupuncture and Tuina College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Acupuncture, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Neurol. 2024 Jul 17;15:1420201. doi: 10.3389/fneur.2024.1420201. eCollection 2024.
Several studies have reported associations between various autoimmune diseases and migraine. Using Mendelian randomization (MR), this study aimed to evaluate the interplay between autoimmune diseases and migraine.
Here, instrumental variables, exposure factors, and outcome factors for 10 common autoimmune diseases and migraine and its subtypes were screened. This screening utilized comprehensive statistics from Europe's largest genome-wide association study and performed reverse MR analysis on positive results. The causality between autoimmune diseases and migraine was comprehensively assessed using multiple analytical methods. Additionally, sensitivity analyses, such as the horizontal diversity heterogeneity and leave-one-out method, were performed.
Random-effects inverse variance weighting analysis revealed a causal correlation between autoimmune hyperthyroidism and migraine ( = 0.0002), and this association was consistent across both migraine with aura (MA; = 0.006) and migraine without aura (MO; = 0.017). In addition, there was a positive causal association between systemic lupus erythematosus (SLE) and MA ( = 0.001) and between hypothyroidism and MO ( = 0.038). There is insufficient evidence to substantiate a causal link between outcomes and other autoimmune-related disorders, and reverse MR results did not reveal a causal relationship between migraines and these autoimmune disorders. The validity of the results was demonstrated by a sensitivity analysis; horizontal pleiotropy and heterogeneity were not observed.
This study observed a positive genetic association between autoimmune hyperthyroidism and migraines. In addition, SLE positively affects MA, and hypothyroidism contributes to the incidence of MO. These results have great significance for future research and prevention of migraine.
多项研究报告了各种自身免疫性疾病与偏头痛之间的关联。本研究采用孟德尔随机化方法（MR），旨在评估自身免疫性疾病与偏头痛之间的相互作用。
在此，筛选了10种常见自身免疫性疾病、偏头痛及其亚型的工具变量、暴露因素和结局因素。该筛选利用了欧洲最大的全基因组关联研究的综合统计数据，并对阳性结果进行了反向MR分析。使用多种分析方法全面评估自身免疫性疾病与偏头痛之间的因果关系。此外，还进行了敏感性分析，如水平多效性异质性分析和留一法分析。
随机效应逆方差加权分析显示自身免疫性甲状腺功能亢进与偏头痛之间存在因果相关性（P = 0.0002），并且这种关联在伴有先兆偏头痛（MA；P = 0.006）和无先兆偏头痛（MO；P = 0.017）中均一致。此外，系统性红斑狼疮（SLE）与MA之间（P = 0.001）以及甲状腺功能减退与MO之间（P = 0.038）存在正向因果关联。没有足够的证据证实结局与其他自身免疫相关疾病之间存在因果联系，反向MR结果也未揭示偏头痛与这些自身免疫性疾病之间的因果关系。敏感性分析证明了结果的有效性；未观察到水平多效性和异质性。
本研究观察到自身免疫性甲状腺功能亢进与偏头痛之间存在正向遗传关联。此外，SLE对MA有正向影响，甲状腺功能减退会导致MO的发生率增加。这些结果对未来偏头痛的研究和预防具有重要意义。
