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POLRMT 过表达与 WNT/β-catenin 信号通路、免疫浸润和肺腺癌患者的不良预后相关。

POLRMT over-expression is linked to WNT/beta-catenin signaling, immune infiltration, and unfavorable outcomes in lung adenocarcinoma patients.

机构信息

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

出版信息

Cancer Med. 2023 Jul;12(14):15691-15703. doi: 10.1002/cam4.6174. Epub 2023 Jun 7.

DOI:10.1002/cam4.6174
PMID:37283308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10417304/
Abstract

BACKGROUND

Mitochondrial RNA polymerase (POLRMT) is essential for the expression of mitochondrial genes. In recent studies, POLRMT expression promoted non-small cell cancer cell proliferation in cell lines and xenografts. The present study investigated the impact of POLRMT expression and function on lung adenocarcinoma (LUAD) patients.

METHOD

Multi-omics data (genomics, transcriptomics, and proteomics) from publicly available databases were used to assess the role of POLRMT expression and function in LUAD. These findings were further verified using cancer tissues from clinical samples.

RESULTS

POLRMT was over-expressed in LUADs, with mutation frequencies ranging from 1.30% to 5.71%. Over-expression of POLRMT was associated with an abnormal clinicopathological condition resulting in a decreased lifespan. Furthermore, gene sets enrich analysis revealed that POLRMT expression was linked to WNT/beta-catenin signaling; the expression of downstream target genes was positively correlated with POLRMT expression. Also, POLRMT expression was positively correlated with immunosuppressive genes, thereby affecting immune infiltration.

CONCLUSION

POLRMT is over-expressed in LUAD, thereby impacting patient survival. It is also involved in WNT/beta-catenin signaling and may affect tumor infiltration.

摘要

背景

线粒体 RNA 聚合酶（POLRMT）对于线粒体基因的表达至关重要。最近的研究表明，POLRMT 表达促进了非小细胞癌细胞在细胞系和异种移植物中的增殖。本研究探讨了 POLRMT 表达和功能对肺腺癌（LUAD）患者的影响。

方法

使用来自公共数据库的多组学数据（基因组学、转录组学和蛋白质组学）来评估 POLRMT 表达和功能在 LUAD 中的作用。使用临床样本中的癌症组织进一步验证了这些发现。

结果

POLRMT 在 LUAD 中过表达，突变频率为 1.30%至 5.71%。POLRMT 的过表达与异常的临床病理状况相关，导致寿命缩短。此外，基因集富集分析表明，POLRMT 表达与 WNT/β-catenin 信号通路有关；下游靶基因的表达与 POLRMT 表达呈正相关。此外，POLRMT 的表达与免疫抑制基因呈正相关，从而影响免疫浸润。

结论

POLRMT 在 LUAD 中过表达，从而影响患者的生存。它还参与 WNT/β-catenin 信号通路，可能影响肿瘤浸润。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/1113b6ce0d06/CAM4-12-15691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/4cbc06e93888/CAM4-12-15691-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/a6689e44cd87/CAM4-12-15691-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/84bf6c0ceddb/CAM4-12-15691-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/66b5d2a4ba4a/CAM4-12-15691-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/1113b6ce0d06/CAM4-12-15691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/4cbc06e93888/CAM4-12-15691-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/a6689e44cd87/CAM4-12-15691-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/84bf6c0ceddb/CAM4-12-15691-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/66b5d2a4ba4a/CAM4-12-15691-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0f/10417304/1113b6ce0d06/CAM4-12-15691-g001.jpg

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