Lei Jiyong, Luo Da, Xiong Jiarui, Li Mingjiang
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Cardiovascular Research Institute, Wuhan University, Wuhan, China.
Front Cardiovasc Med. 2023 May 22;10:1126157. doi: 10.3389/fcvm.2023.1126157. eCollection 2023.
Observational studies have shown a correlation between unpleasant emotions and coronary atherosclerosis, but the underlying causal linkages are still uncertain. We conducted a Mendelian randomization (MR) investigation on two samples for this purpose.
In genome-wide association studies in the UK Biobank (total = 459,561), we selected 40 distinct single-nucleotide polymorphisms (SNPs) related to unpleasant emotions as genome-wide statistically significant instrumental variables. FinnGen consortium provided summary-level data on coronary atherosclerosis for 211,203 individuals of Finnish descent. MR-Egger regression, the inverse variance weighted technique (IVW), and the weighted median method were used in the process of conducting data analysis.
There was sufficient evidence to establish a causal connection between unpleasant emotions and coronary atherosclerosis risk. For each unit increase in the log-odds ratio of unpleasant feelings, the odds ratios were 3.61 (95% CI: 1.64-7.95; = 0.001). The outcomes of sensitivity analyses were comparable. There was no indication of heterogeneity or directional pleiotropy.
Our findings provide causal evidence for the effects of unpleasant emotions on coronary atherosclerosis.
观察性研究表明不愉快情绪与冠状动脉粥样硬化之间存在关联，但潜在的因果联系仍不确定。为此，我们对两个样本进行了孟德尔随机化（MR）研究。
在英国生物银行的全基因组关联研究中（共459,561人），我们选择了40个与不愉快情绪相关的不同单核苷酸多态性（SNP）作为全基因组统计学显著的工具变量。芬兰基因联盟提供了211,203名芬兰裔个体冠状动脉粥样硬化的汇总数据。在数据分析过程中使用了MR-Egger回归、逆方差加权技术（IVW）和加权中位数法。
有充分证据表明不愉快情绪与冠状动脉粥样硬化风险之间存在因果关系。不愉快情绪的对数优势比每增加一个单位，优势比为3.61（95%可信区间：1.64 - 7.95；P = 0.001）。敏感性分析结果相似。没有异质性或定向多效性的迹象。
我们的研究结果为不愉快情绪对冠状动脉粥样硬化的影响提供了因果证据。
