Lassmann Hans
Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Free Neuropathol. 2020 Jan 11;1:3. doi: 10.17879/fnp-2020-2612. eCollection 2020 Jan.
Ten neuropathological studies, published in 2019, are discussed, which address important aspects of neuroimmunology and inflammatory brain disease. They include topics related to new mechanisms of inflammation and immune mediated neurodegeneration, which are relevant for multiple sclerosis (publications 1 to 4) and discuss the role of specific autoantibodies against myelin oligodendrocyte glycoprotein or aquaporin 4 in neuromyelitis optica spectrum disorders (publications 5 and 6). Other studies highlight the discovery of new virus induced diseases of the nervous system and their relevance for clinical neurology and diagnostic neuropathology (publications 7 and 8). Finally, very interesting studies are discussed dealing with microglia and immune mechanisms in neurodegeneration (publication 9) and the neuropathological long-term outcome of Aß vaccination in Alzheimer's disease (publication 10). All these studies highlight the central role of neuropathology in neurological disease research.
本文讨论了2019年发表的十项神经病理学研究，这些研究涉及神经免疫学和炎症性脑疾病的重要方面。它们包括与炎症和免疫介导的神经退行性变新机制相关的主题，这些主题与多发性硬化症相关（出版物1至4），并讨论了针对髓鞘少突胶质细胞糖蛋白或水通道蛋白4的特异性自身抗体在视神经脊髓炎谱系障碍中的作用（出版物5和6）。其他研究强调了新发现的病毒诱导的神经系统疾病及其与临床神经病学和诊断神经病理学的相关性（出版物7和8）。最后，讨论了关于神经退行性变中的小胶质细胞和免疫机制的非常有趣的研究（出版物9）以及阿尔茨海默病中Aβ疫苗接种的神经病理学长期结果（出版物10）。所有这些研究都突出了神经病理学在神经疾病研究中的核心作用。
