Alderman B W, Weiss N S, Daling J R, Ure C L, Ballard J H
Am J Epidemiol. 1986 Aug;124(2):262-7. doi: 10.1093/oxfordjournals.aje.a114384.
This case-control study was designed to investigate the relation between reproductive history and occurrence of hip and forearm fractures in postmenopausal women. Three hundred and fifty-five King County, Washington women who sustained a fracture between 1976 and 1980 and 562 control women were interviewed regarding their reproductive history and other factors. After controlling for the confounding effects of age, obesity, and use of noncontraceptive estrogens, the authors found that women who gave birth four or more times had a risk of fracture similar to women who had not given birth (odds ratio = 1.2, 95% confidence interval = 0.7-2.2), and women who breastfed for more than two years had a risk of fracture similar to women who had never breastfed (odds ratio = 0.8, 95% confidence interval = 0.4-1.5).
这项病例对照研究旨在调查绝经后女性的生殖史与髋部和前臂骨折发生率之间的关系。对1976年至1980年间发生骨折的355名华盛顿州金县女性以及562名对照女性进行了关于她们生殖史及其他因素的访谈。在控制了年龄、肥胖和非避孕雌激素使用等混杂因素的影响后，作者发现生育四次或更多次的女性骨折风险与未生育女性相似（优势比=1.2，95%置信区间=0.7 - 2.2），母乳喂养超过两年的女性骨折风险与从未母乳喂养的女性相似（优势比=0.8，95%置信区间=0.4 - 1.5）。
