Chair of Fundamental Sciences, Department of Human Anatomy, Medical University of Lublin, Kazimierza Jaczewskiego 4, 20-090, Lublin, Poland.
Department of Foreign Languages, Interfaculty Centre for Didactics, Medical University of Lublin, 20-081, Lublin, Poland.
Amino Acids. 2023 Jul;55(7):835-851. doi: 10.1007/s00726-023-03281-6. Epub 2023 Jun 7.
Since the beginning of SESN protein development, they have attracted highly progressive attention due to their regulatory role in multiple signalling pathways. Through their antioxidant activity and autophagy regulation implication, they can function as powerful antioxidants to reduce oxidative stress in cells. SESN proteins received special attention in the field of regulation of reactive oxygen species level in the cell and its interplay with signalling pathways determining energy and nutrient homeostasis. Since perturbations in these pathways are implicated in cancer onset and development, SESNs might constitute potential novel therapeutic targets of broad interest. In this review, we discuss the impact of SESN proteins on anti-cancer therapy based on naturally occurring compounds and conventionally used drugs that influence oxidative stress and autophagy-induced cellular signalling pathways. The significant changes in reactive oxygen species level and nutrient status in cancer cells generate subsequent biological effect through the regulation of SESN-dependent pathways. Thus, SESN may serve as the key molecule for regulating anti-cancer drugs' induced cellular response.
自 SESN 蛋白被发现以来，由于其在多种信号通路中的调节作用，它们引起了高度的关注。通过抗氧化活性和自噬调节作用，SESN 蛋白可以作为强大的抗氧化剂，减少细胞中的氧化应激。SESN 蛋白在细胞内活性氧水平的调节及其与决定能量和营养稳态的信号通路的相互作用领域受到特别关注。由于这些途径的干扰与癌症的发生和发展有关，因此 SESN 可能成为具有广泛兴趣的潜在新型治疗靶点。在这篇综述中，我们讨论了基于影响氧化应激和自噬诱导细胞信号通路的天然存在的化合物和常规使用的药物，SESN 蛋白对癌症治疗的影响。癌细胞中活性氧水平和营养状态的显著变化通过 SESN 依赖性途径的调节产生后续的生物学效应。因此，SESN 可以作为调节抗癌药物诱导的细胞反应的关键分子。
