Vleugels M P, Eling W M, Rolland R, de Graaf R
Am J Obstet Gynecol. 1986 Jul;155(1):118-21. doi: 10.1016/0002-9378(86)90092-x.
Data are presented of a study on the relationship between cortisol, amenorrhea, parity, and age among pregnant women. Total cortisol concentrations were measured by a radioimmunoassay in healthy pregnant women (n = 527), including 105 nulliparas and 422 multiparas. The serum concentration of total cortisol increased linearly with progression of amenorrhea. Significantly higher cortisol levels were found in nulliparas compared to multiparas and independent of amenorrhea. Since parity and age are strongly correlated, age-dependent changes may contribute to the difference in cortisol level between nulliparas and multiparas. Analysis of the age-dependent changes on this difference in cortisol level showed no significant influence.
本文呈现了一项关于孕妇皮质醇、闭经、胎次和年龄之间关系的研究数据。通过放射免疫分析法测定了527名健康孕妇的总皮质醇浓度，其中包括105名初产妇和422名经产妇。总皮质醇的血清浓度随闭经进展呈线性增加。与经产妇相比，初产妇的皮质醇水平显著更高，且与闭经无关。由于胎次和年龄密切相关，年龄依赖性变化可能导致初产妇和经产妇皮质醇水平的差异。对皮质醇水平差异的年龄依赖性变化分析显示无显著影响。
