Santagati G, Zibetti G, Forgione F, Spaghi A
Minerva Med. 1979 Feb 18;70(8):595-603.
A controlled clinical trial was made of the anti-ammoniaemic properties of gamma-ethylester glutamic acid, arginine and placebo in a series of 45 patients with hepatic insufficiency characterized by hyperammonemia (excluding cases of pre-coma and coma) randomly assigned to three groups for treatment with: gamma-ethylester of glutamic acid (25 g), l-arginine (25 g) and physiological solution in identical 500 ml bottles. Various parameters were controlled. The results obtained were assessed with different statistical techniques, depending on the parameter concerned and the aims of the trial. Blood ammoniaemia was significantly decreased by both-ethylester of glutamic acid and arginine though the former was more effective quantitatively and in terms of time. SGOT and BSF values also followed the same pattern.
对45例以高氨血症为特征的肝功能不全患者（不包括昏迷前期和昏迷病例）进行了一项对照临床试验，将其随机分为三组，分别用以下药物治疗：谷氨酸γ - 乙酯（25克）、L - 精氨酸（25克）和置于500毫升相同瓶子中的生理盐水。对各项参数进行了控制。根据相关参数和试验目的，采用不同的统计技术对所得结果进行评估。谷氨酸乙酯和精氨酸均可使血氨水平显著降低，不过前者在降低血氨的量和时间方面更有效。谷草转氨酶（SGOT）和碱性磷酸酶（BSF）值也呈现相同趋势。
