Marchina M M, Renzi G, Serofilli S
Minerva Med. 1979 Mar 3;70(11):811-8.
After considering the physiopathological mechanisms of ammoniac metabolism and the different causes of hyperammonaemia in subjects whose organisms present the weak biological equilibrium of the elderly, the antiammonaemic activity of gamma-ethylester of glutamic acid and that of arginine have been compared in a controlled double-blind trial. 45 old patients suffering from hepatic insufficiency characterized by hyperammonaemia and correlated neurological symptomatology have been treated. The subjects, subdivided at random into groups of 15, were treated for an average of 8.8 days with gamma-ethylester of glutamic acid, arginine and placebo presented in identical 500 ml bottles. The posology of the active ingredients ranged form a maximum of 25 g to a minimum of 10 g. The results obtained show that gamma-ethylester of glutamic acid and arginine has significantly greater antiammonemic activity than placebo and that gamma-ethylester of glutamic acid is significantly more effective than arginine. As regards the improvement in neuropsychic symptomatology, the clear superiority of gamma-ethylester of glutamic acid versus both arginine and placebo non evident.
在考虑了氨代谢的生理病理机制以及机体呈现老年人脆弱生物平衡的受试者高氨血症的不同病因之后，在一项对照双盲试验中比较了谷氨酸γ-乙酯和精氨酸的抗氨活性。对45例患有以高氨血症和相关神经症状为特征的肝功能不全的老年患者进行了治疗。将受试者随机分为15人一组，分别用装在相同500毫升瓶子中的谷氨酸γ-乙酯、精氨酸和安慰剂治疗，平均治疗8.8天。活性成分的剂量范围为最大25克至最小10克。所获得的结果表明，谷氨酸γ-乙酯和精氨酸的抗氨活性明显高于安慰剂，并且谷氨酸γ-乙酯比精氨酸明显更有效。至于神经精神症状的改善，谷氨酸γ-乙酯相对于精氨酸和安慰剂的明显优势并不明显。
