Santagati G, Zibetti G, Grignani A
Minerva Med. 1978 Apr 28;69(20):1367-74.
The AA. administered i.v. large doses of gamma-ethylester of glutamic acid to 22 patients affected with severe liver failure associated to mental and neuromuscolar abnormalities as tremors, confusion, restlesness which have been duly recorded for the purpose of this evaluation. The average daily dose was 36.3 gm and the treatment lasted as an average 9.5 days. The peripheral venous blood ammonia was checked, at the beginning and at the end of the treatment, in all the patients and in some, at random, the following parameters were determined: pH, pCO2, pO2, HCO3, TCO2, oxygen saturation on arterial blood. The treatment caused a statistically remarkable decrease of blood ammonia in 21 of 22 patients. The mental and neuromuscolar abnormalities too showed a statistically important downward trend vs. the basal values. The acid-base balance did not record any remarkable variation. The AA. judge as absolutely positive the trial carried out with gamma-ethylester of glutamic acid. The large doses used caused clear-cut and dramatic improvements and were estremely well tolerated.
研究人员对22例患有严重肝功能衰竭并伴有精神和神经肌肉异常（如震颤、意识模糊、烦躁不安）的患者静脉注射了大剂量的谷氨酸γ-乙酯，为此次评估已对这些症状进行了适当记录。平均每日剂量为36.3克，治疗平均持续9.5天。在所有患者治疗开始和结束时均检测了外周静脉血氨，并且随机对部分患者测定了以下参数：pH值、二氧化碳分压、氧分压、碳酸氢根、总二氧化碳、动脉血氧饱和度。治疗使22例患者中的21例血氨出现统计学上的显著下降。与基础值相比，精神和神经肌肉异常也呈现出统计学上的显著下降趋势。酸碱平衡未出现任何显著变化。研究人员认为使用谷氨酸γ-乙酯进行的试验结果绝对呈阳性。所使用的大剂量药物带来了明确且显著的改善，并且耐受性极佳。
