School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
School of Pharmacy, Chengdu Medical College, Chengdu 610500, China.
Int J Biol Macromol. 2023 Jul 1;242(Pt 4):125198. doi: 10.1016/j.ijbiomac.2023.125198. Epub 2023 Jun 5.
A quaternized chitosan (QCS)@poly(ionic liquid) (PIL) hydrogel adhesive was prepared by in-situ ultraviolet (UV)-induced copolymerization of 1-vinyl-3-butyl imidazolium bromide ([BVIm][Br]) and methacryloyloxyethyl trimethylammonium chloride (DMC) in QCS aqueous solution without using any crosslinkers, which was stably crosslinked by reversible hydrogen bonding together with ion association and exhibited excellent adhesion, plasticity, conductivity and recyclability properties. Moreover, its thermal/pH-responsive behaviors and intermolecular interaction mechanism of thermal-triggered reversible adhesion were discovered, meanwhile good biocompatibility, antibacterial properties, repeated stickiness and degradability were also proved. The results showed that the newly developed hydrogel could make various tissues, organic, inorganic or metal materials adhered tightly within 1 min; after 10 binding-peeling cycles, the adhesive strength to glass, plastic, aluminum and porcine skin still remained beyond 96 %, 98 %, 92 % and 71 % of the original, respectively. The adhesion mechanism involves ion dipole interaction, electrostatic interaction, hydrophobic interaction, coordination, cation-π interaction, H-bonding and van der Waals force. For above merits, the new tricomponent hydrogel is expected to be applied in biomedical field to achieve adjustable adhesion and on-demand peeling.
一种季铵化壳聚糖（QCS）@聚离子液体（PIL）水凝胶粘合剂是通过在 QCS 水溶液中就地紫外（UV）引发 1-乙烯基-3-丁基咪唑溴化物（[BVIm][Br]）和甲基丙烯酰氧乙基三甲基氯化铵（DMC）的共聚反应而制备的，无需使用任何交联剂，它通过可逆氢键交联以及离子缔合稳定，表现出优异的粘附性、可塑性、导电性和可回收性。此外，还发现了其热/ pH 响应行为和热触发可逆粘附的分子间相互作用机制，同时还证明了良好的生物相容性、抗菌性能、可重复粘性和可降解性。结果表明，新开发的水凝胶可以在 1 分钟内使各种组织、有机、无机或金属材料紧密粘附；经过 10 次粘合-剥离循环后，对玻璃、塑料、铝和猪皮的粘附强度仍分别保持在原始强度的 96%、98%、92%和 71%以上。粘附机制涉及离子偶极相互作用、静电相互作用、疏水相互作用、配位、阳离子-π 相互作用、氢键和范德华力。鉴于这些优点，新型三组分水凝胶有望应用于生物医学领域，以实现可调节的粘附和按需剥离。
