Hammer M E, Mullen P W, Ferguson J G, Pai S, Cosby C, Jackson K L
Am J Ophthalmol. 1986 Jul 15;102(1):1-6. doi: 10.1016/0002-9394(86)90200-x.
In a prospective study of 328 high-risk neonates, we used computer-assisted logistic regression of 47 potential risk factors to study acute retinopathy of prematurity. Only four factors were significant in the logistic regression equation: ventilator hours, xanthine administration, birthweight, and maternal bleeding. Xanthine administration was identified as a new independent and significant (P less than .0001) predictor of acute retinopathy of prematurity.
在一项针对328名高危新生儿的前瞻性研究中，我们对47个潜在风险因素进行了计算机辅助逻辑回归分析，以研究早产儿急性视网膜病变。在逻辑回归方程中，只有四个因素具有显著性：机械通气时长、黄嘌呤给药、出生体重和母体出血。黄嘌呤给药被确定为早产儿急性视网膜病变一个新的独立且具有显著性（P小于0.0001）的预测因素。
