Borțea Claudia Ioana, Stoica Florina, Boia Marioara, Iacob Emil Radu, Dinu Mihai, Iacob Roxana, Iacob Daniela
Department of Neonatology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Department of Ophthalmology, Emergency Municipal Clinical Hospital, Gheorghe Dima Street 5, 300254 Timisoara, Romania.
Medicina (Kaunas). 2021 Apr 27;57(5):420. doi: 10.3390/medicina57050420.
: Retinopathy of prematurity (ROP) is the leading cause of blindness in preterm infants. We studied the relationship between different perinatal characteristics, i.e., sex; gestational age (GA); birth weight (BW); C-reactive protein (CRP) and lactate dehydrogenase (LDH) concentrations; ventilation, continuous positive airway pressure (CPAP), and surfactant administration; and the incidence of Stage 1-3 ROP. : This study included 247 preterm infants with gestational age (GA) < 32 weeks that were successfully screened for ROP. Univariate and multivariate binary analyses were performed to find the most significant risk factors for ROP (Stage 1-3), while multivariate multinomial analysis was used to find the most significant risk factors for specific ROP stages, i.e., Stage 1, 2, and 3. : The incidence of ROP (Stage 1-3) was 66.40% (164 infants), while that of Stage 1, 2, and 3 ROP was 15.38% (38 infants), 27.53% (68 infants), and 23.48% (58 infants), respectively. Following univariate analysis, multiple perinatal characteristics, i.e., GA; BW; and ventilation, CPAP, and surfactant administration, were found to be statistically significant risk factors for ROP ( 0.001). However, in a multivariate model using the same characteristics, only BW and ventilation were significant ROP predictors ( 0.001 and 0.05, respectively). Multivariate multinomial analysis revealed that BW was only significantly correlated with Stage 2 and 3 ROP ( 0.05 and 0.001, respectively), while ventilation was only significantly correlated with Stage 2 ROP ( 0.05). : The results indicate that GA; BW; and the use of ventilation, CPAP, and surfactant were all significant risk factors for ROP (Stage 1-3), but only BW and ventilation were significantly correlated with ROP and specific stages of the disease, namely Stage 2 and 3 ROP and Stage 2 ROP, respectively, in multivariate models.
早产儿视网膜病变（ROP）是早产婴儿失明的主要原因。我们研究了不同围产期特征之间的关系，即性别、胎龄（GA）、出生体重（BW）、C反应蛋白（CRP）和乳酸脱氢酶（LDH）浓度、通气、持续气道正压通气（CPAP）和表面活性剂的使用，以及1-3期ROP的发病率。本研究纳入了247例胎龄（GA）<32周且成功筛查ROP的早产婴儿。进行单变量和多变量二元分析以找出ROP（1-3期）最显著的危险因素，而多变量多项分析用于找出特定ROP阶段（即1期、2期和3期）最显著的危险因素。ROP（1-3期）的发病率为66.40%（164例婴儿），而1期、2期和3期ROP的发病率分别为15.38%（38例婴儿）、27.53%（68例婴儿）和23.48%（58例婴儿）。单变量分析后发现，多个围产期特征，即GA、BW以及通气、CPAP和表面活性剂的使用，是ROP的统计学显著危险因素（P<0.001）。然而，在使用相同特征的多变量模型中，只有BW和通气是ROP的显著预测因素（分别为P<0.001和P<0.05）。多变量多项分析显示，BW仅与2期和3期ROP显著相关（分别为P<0.05和P<0.001），而通气仅与2期ROP显著相关（P<0.05）。结果表明，GA、BW以及通气、CPAP和表面活性剂的使用都是ROP（1-3期）的显著危险因素，但在多变量模型中，只有BW和通气分别与ROP及其特定阶段（即2期和3期ROP以及2期ROP）显著相关。
