Khan Nadeem G, Tungekar Bushra, Adiga Divya, Chakrabarty Sanjiban, Rai Padmalatha S, Kabekkodu Shama Prasada
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India; Center for DNA Repair and Genome Stability (CDRGS), Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119505. doi: 10.1016/j.bbamcr.2023.119505. Epub 2023 Jun 5.
Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. Its structural similarity with estrogen makes it an endocrine-disrupting chemical. BPA can disrupt signaling pathways at very low doses and may cause organellar stress. According to in vitro and in vivo studies, BPA interacts with various cell surface receptors to cause organellar stress, producing free radicals, cellular toxicity, structural changes, DNA damage, mitochondrial dysfunction, cytoskeleton remodeling, centriole duplication, and aberrant changes in several cell signaling pathways. The current review summarizes the impact of BPA exposure on the structural and functional aspects of subcellular components of cells such as the nucleus, mitochondria, endoplasmic reticulum, lysosome, ribosome, Golgi apparatus, and microtubules and its consequent impact on human health.
双酚A（BPA）是一种部分溶于水的化学物质，呈固态。它与雌激素的结构相似性使其成为一种内分泌干扰化学物质。双酚A在极低剂量下就能干扰信号通路，并可能导致细胞器应激。根据体外和体内研究，双酚A与各种细胞表面受体相互作用，引发细胞器应激，产生自由基、细胞毒性、结构变化、DNA损伤、线粒体功能障碍、细胞骨架重塑、中心粒复制以及多个细胞信号通路的异常变化。本综述总结了双酚A暴露对细胞核、线粒体、内质网、溶酶体、核糖体、高尔基体和微管等细胞亚细胞成分的结构和功能方面的影响及其对人类健康的后续影响。
