Institute of Environmental Engineering, Ajou University, Suwon, South Korea.
Department of Environmental Engineering, Ajou University, Suwon, South Korea.
Crit Rev Biotechnol. 2024 Jun;44(4):530-546. doi: 10.1080/07388551.2023.2176740. Epub 2023 Jun 7.
1,4-Butanediol (1,4-BDO) is a valuable industrial chemical that is primarily produced via several energy-intensive petrochemical processes based on fossil-based raw materials, leading to issues related to: non-renewability, environmental contamination, and high production costs. 1,4-BDO is used in many chemical reactions to develop a variety of useful, valuable products, such as: polyurethane, Spandex intermediates, and polyvinyl pyrrolidone (PVP), a water-soluble polymer with numerous personal care and pharmaceutical uses. In recent years, to satisfy the growing need for 1,4-BDO, there has been a major shift in focus to sustainable bioproduction via microorganisms using: recombinant strains, metabolic engineering, synthetic biology, enzyme engineering, bioinformatics, and artificial intelligence-guided algorithms. This article discusses the current status of the development of: various chemical and biological production techniques for 1,4-BDO, advances in biological pathways for 1,4-BDO biosynthesis, prospects for future production strategies, and the difficulties associated with environmentally friendly and bio-based commercial production strategies.
1,4-丁二醇（1,4-BDO）是一种有价值的工业化学品，主要通过几种基于化石原料的能源密集型石油化工工艺生产，由此带来了与不可再生性、环境污染和高生产成本相关的问题。1,4-BDO 用于许多化学反应中，以开发各种有用的、有价值的产品，如：聚氨酯、氨纶中间体和聚乙烯吡咯烷酮（PVP），一种具有多种个人护理和制药用途的水溶性聚合物。近年来，为了满足对 1,4-BDO 的不断增长的需求，人们的关注重点已发生重大转变，即通过使用重组菌株、代谢工程、合成生物学、酶工程、生物信息学和人工智能引导算法的微生物进行可持续的生物生产。本文讨论了 1,4-BDO 的各种化学和生物生产技术的发展现状、1,4-BDO 生物合成的生物途径的进展、未来生产策略的前景，以及与环保和基于生物的商业生产策略相关的困难。
