Reynolds J D, Griebel M, Mallory S, Steele R
Am J Ophthalmol. 1986 Jul 15;102(1):33-6. doi: 10.1016/0002-9394(86)90205-9.
An 1,810-g girl born at 37 weeks of gestation had true congenital herpes simplex virus type 2 infection. The neonate was born with hypo-pigmented skin lesions, brain lesions, and old heavily pigmented retinal scars in the posterior pole. There was no active ocular disease. Viral cultures, immunoperoxidase stains, and antibody determination by enzyme-linked immunosorbent assay were all positive for herpes simplex virus. Treatment with acyclovir healed the lesions within ten days. The clinical and laboratory findings indicated that the herpetic infection probably occurred in the second trimester.
一名孕37周出生、体重1810克的女婴患有真正的先天性2型单纯疱疹病毒感染。该新生儿出生时伴有色素减退性皮肤病变、脑部病变以及后极部陈旧性色素沉着严重的视网膜瘢痕。当时没有活动性眼部疾病。病毒培养、免疫过氧化物酶染色以及通过酶联免疫吸附测定法进行的抗体检测结果均显示单纯疱疹病毒呈阳性。使用阿昔洛韦治疗后，病变在十天内愈合。临床和实验室检查结果表明，疱疹感染可能发生在孕中期。
