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小鼠后肢联合卸载与辐射暴露后骨骼肌中的髓样细胞浸润

Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice.

作者信息

Emanuelsson Eric B, Baselet Bjorn, Neefs Mieke, Baatout Sarah, Proesmans Brit, Daenen Lisa, Sundberg Carl Johan, Rundqvist Helene, Fernandez-Gonzalo Rodrigo

机构信息

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Radiobiology unit, SCK CEN, Belgian Nuclear Research Centre, Mol, Belgium.

出版信息

NPJ Microgravity. 2023 Jun 7;9(1):40. doi: 10.1038/s41526-023-00289-w.

DOI:10.1038/s41526-023-00289-w
PMID:37286567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10247796/
Abstract

The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.

摘要

骨骼肌和免疫系统受到太空环境的严重影响。这些器官之间的相互作用虽然已经确立，但尚未完全了解。本研究确定了小鼠骨骼肌在（后肢）卸载并结合急性辐照（HLUR）后免疫细胞变化的性质。我们的研究结果表明，14天的HLUR会导致骨骼肌中髓样免疫细胞浸润显著增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d93/10247796/141a6437ecf5/41526_2023_289_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d93/10247796/d1c476f70f18/41526_2023_289_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d93/10247796/141a6437ecf5/41526_2023_289_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d93/10247796/d1c476f70f18/41526_2023_289_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d93/10247796/141a6437ecf5/41526_2023_289_Fig2_HTML.jpg

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本文引用的文献

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RNA sequencing (RNA-seq) analysis of gene expression provides new insights into hindlimb unloading-induced skeletal muscle atrophy.基因表达的RNA测序（RNA-seq）分析为后肢去负荷诱导的骨骼肌萎缩提供了新的见解。
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2
Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!炎症与骨骼肌再生：巨噬细胞来搞定！
Trends Immunol. 2020 Jun;41(6):481-492. doi: 10.1016/j.it.2020.04.006. Epub 2020 Apr 30.
3
T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle.
T细胞受体特异性驱动急性损伤骨骼肌内具有修复功能的调节性T细胞群体的积累。
Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26727-26733. doi: 10.1073/pnas.1914848116. Epub 2019 Dec 10.
4
The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points.制动和炎症对肌肉质量和胰岛素抵抗调节的影响：殊途同归。
J Physiol. 2019 Mar;597(5):1259-1270. doi: 10.1113/JP275444. Epub 2018 Aug 18.
5
Skeletal muscle regeneration is modulated by inflammation.骨骼肌再生受炎症调节。
J Orthop Translat. 2018 Feb 7;13:25-32. doi: 10.1016/j.jot.2018.01.002. eCollection 2018 Apr.
6
Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair.浸润型巨噬细胞在早期被广泛激活，以支持急性骨骼肌损伤修复。
J Neuroimmunol. 2018 Apr 15;317:55-66. doi: 10.1016/j.jneuroim.2018.01.004. Epub 2018 Jan 4.
7
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