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Perivascular spaces relate to the course and cognition of Huntington's disease.

作者信息

Li Xiao-Yan, Xie Juan-Juan, Wang Jin-Hong, Bao Yu-Feng, Dong Yi, Gao Bin, Shen Ting, Huang Pei-Yu, Ying Hao-Chao, Xu Han, Roe Anna Wang, Lai Hsin-Yi, Wu Zhi-Ying

机构信息

Department of Medical Genetics and Center for Rare Diseases, Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.

Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical Engineering and Instrument Science, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China.

出版信息

Transl Neurodegener. 2023 May 15;12(1):30. doi: 10.1186/s40035-023-00359-9.

DOI:10.1186/s40035-023-00359-9
PMID:37287074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10245407/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5117/10245407/5514cd3f36ab/40035_2023_359_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5117/10245407/5514cd3f36ab/40035_2023_359_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5117/10245407/5514cd3f36ab/40035_2023_359_Fig1_HTML.jpg

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2
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Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease.沿血管周围间隙扩散作为亨廷顿舞蹈病中类淋巴系统损伤的标志物
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Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington's disease mice.

本文引用的文献

1
Local and Global Abnormalities in Pre-symptomatic Huntington's Disease Revealed by 7T Resting-state Functional MRI.7T静息态功能磁共振成像揭示症状前亨廷顿舞蹈症的局部和整体异常
Neurosci Bull. 2023 Jan;39(1):94-98. doi: 10.1007/s12264-022-00943-5. Epub 2022 Aug 29.
2
3D Segmentation of Perivascular Spaces on T1-Weighted 3 Tesla MR Images With a Convolutional Autoencoder and a U-Shaped Neural Network.使用卷积自动编码器和U型神经网络对3特斯拉T1加权磁共振图像上的血管周围间隙进行3D分割
Front Neuroinform. 2021 Jun 18;15:641600. doi: 10.3389/fninf.2021.641600. eCollection 2021.
3
Fronto-striatal circuits for cognitive flexibility in far from onset Huntington's disease: evidence from the Young Adult Study.
血浆和脑脊液神经丝轻链浓度升高在亨廷顿病小鼠的大脑中响应于突变亨廷顿蛋白降低而稳定。
Transl Neurodegener. 2024 Oct 8;13(1):50. doi: 10.1186/s40035-024-00443-8.
4
Meta-analysis of the relationship between the number and location of perivascular spaces in the brain and cognitive function.脑内血管周围间隙数量和位置与认知功能关系的荟萃分析。
Neurol Sci. 2024 Aug;45(8):3743-3755. doi: 10.1007/s10072-024-07438-3. Epub 2024 Mar 9.
5
Mild cognitive impairment in Huntington's disease: challenges and outlooks.亨廷顿病患者的轻度认知障碍：挑战与展望。
J Neural Transm (Vienna). 2024 Apr;131(4):289-304. doi: 10.1007/s00702-024-02744-8. Epub 2024 Jan 24.
额颞叶皮质回路对远未发病的亨廷顿病患者认知灵活性的作用：来自青年研究的证据。
J Neurol Neurosurg Psychiatry. 2021 Feb;92(2):143-149. doi: 10.1136/jnnp-2020-324104. Epub 2020 Oct 31.
4
Association of Dilated Perivascular Spaces and Disease Severity in Patients With Huntington Disease.亨廷顿病患者的血管周围间隙扩张与疾病严重程度的关系。
Neurology. 2021 Feb 9;96(6):e890-e894. doi: 10.1212/WNL.0000000000011121. Epub 2020 Oct 26.
5
Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis.亨廷顿病青年研究（HD-YAS）中基因携带者的生物学和临床特征：一项横断面分析。
Lancet Neurol. 2020 Jun;19(6):502-512. doi: 10.1016/S1474-4422(20)30143-5. Epub 2020 May 26.
6
Perivascular spaces in the brain: anatomy, physiology and pathology.脑内血管周围间隙：解剖、生理与病理。
Nat Rev Neurol. 2020 Mar;16(3):137-153. doi: 10.1038/s41582-020-0312-z. Epub 2020 Feb 24.
7
Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease.结构神经影像学将哥伦比亚亨廷顿病家族的易感性与疾病表现区分开来。
Brain Behav. 2019 Aug;9(8):e01343. doi: 10.1002/brb3.1343. Epub 2019 Jul 5.
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Multi-channel multi-scale fully convolutional network for 3D perivascular spaces segmentation in 7T MR images.多通道多尺度全卷积网络用于 7T MR 图像中血管周围空间的分割。
Med Image Anal. 2018 May;46:106-117. doi: 10.1016/j.media.2018.02.009. Epub 2018 Feb 27.
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Structured Learning for 3-D Perivascular Space Segmentation Using Vascular Features.基于血管特征的 3D 血管周围空间分割的结构化学习。
IEEE Trans Biomed Eng. 2017 Dec;64(12):2803-2812. doi: 10.1109/TBME.2016.2638918. Epub 2017 Mar 1.
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Huntington disease: natural history, biomarkers and prospects for therapeutics.亨廷顿病：自然史、生物标志物和治疗前景。
Nat Rev Neurol. 2014 Apr;10(4):204-16. doi: 10.1038/nrneurol.2014.24. Epub 2014 Mar 11.