埃塞俄比亚东部哈勒尔市公立医院医护人员中[具体病菌名称未给出]的鼻腔携带率、相关因素及抗菌药物敏感性模式
Nasal Carriage Rate of , Its Associated Factors, and Antimicrobial Susceptibility Pattern Among Health Care Workers in Public Hospitals, Harar, Eastern Ethiopia.
作者信息
Wolde Wondimagegn, Mitiku Habtamu, Sarkar Rajesh, Shume Tadesse
机构信息
Department of Medical Microbiology and Immunology, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
Department of Tropical and Infectious Disease and Parasitology, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
出版信息
Infect Drug Resist. 2023 Jun 2;16:3477-3486. doi: 10.2147/IDR.S396570. eCollection 2023.
BACKGROUND
is the bacteria that colonizes the nasal nares of health-care workers and serves as a reservoir for the spread of pathogen for subsequent infections, mainly Methicillin-resistant . However, there is a limited study conducted regarding this topic in Harar, Eastern Ethiopia.
OBJECTIVE
The main objective of this study was to determine the prevalence of nasal carriage of , associated factors and antimicrobial susceptibility patterns among health-care workers of public hospitals in Harar, Eastern Ethiopia from May 15 to July 30, 2021.
METHODS
A hospital-based cross-sectional study was conducted on 295 health-care workers. A simple random sampling technique was used to select the participant. Nasal swabs were collected and cultured at 35°C for 24hrs. was identified using the coagulase test and catalase test. Methicillin resistance (MRSA) was screened using a cefoxitin disc on Muller Hinton agar using the Kirby-Bauer disc diffusion method. Data were entered into EPI-Info version-7 and transferred to SPSS-20 for analysis. Factors associated with nasal carriage of were determined by using chi-square analysis. A -value of less than 0.05 was considered statistically significant.
RESULTS
The prevalence of in this study was 15.6% (95% CI: 11.7%, 20.3%) and methicillin-resistant was 11.2% (95% CI: 7.8%, 15.4%), respectively. Age (P < 0.001), work experience (p < 0.001), working unit (p < 0.02), antibiotic use within 3 months (p < 0.001), hand washing habit (p < 0.01), hand rub use (p < 0.001), living with smokers (p < 0.001), living with pets (p < 0.001) and having chronic diseases (p < 0.001) were found significantly associated with nasal carriage.
CONCLUSION
The prevalence of and Methicillin-resistant are high in our study. The study emphasizes the need for regular surveillance among hospital staff and the environment to prevent MRSA transmission among health-care personnel.
背景
是一种定植于医护人员鼻腔的细菌，是后续感染病原体传播的储存库，主要是耐甲氧西林的。然而，在埃塞俄比亚东部的哈勒尔，关于这个主题的研究有限。
目的
本研究的主要目的是确定2021年5月15日至7月30日埃塞俄比亚东部哈勒尔公立医院医护人员鼻腔携带的流行率、相关因素和抗菌药物敏感性模式。
方法
对295名医护人员进行了一项基于医院的横断面研究。采用简单随机抽样技术选择参与者。采集鼻拭子并在35°C下培养24小时。使用凝固酶试验和过氧化氢酶试验进行鉴定。使用头孢西丁纸片在Muller Hinton琼脂上采用Kirby-Bauer纸片扩散法筛选耐甲氧西林（MRSA）。数据录入EPI-Info 7版本并转移到SPSS-20进行分析。使用卡方分析确定与鼻腔携带相关的因素。P值小于0.05被认为具有统计学意义。
结果
本研究中鼻腔携带的流行率为15.6%（95%CI：11.7%，20.3%），耐甲氧西林的流行率为11.2%（95%CI：7.8%，15.4%）。年龄（P<0.001）、工作经验（p<0.001）、工作单位（p<0.02）、3个月内使用抗生素（p<0.001）、洗手习惯（p<0.01）、使用手消毒剂（p<0.001）、与吸烟者同住（p<0.001）、与宠物同住（p<0.001）和患有慢性病（p<0.001）被发现与鼻腔携带显著相关。
结论
在我们的研究中，鼻腔携带和耐甲氧西林的流行率很高。该研究强调需要对医院工作人员和环境进行定期监测，以防止医护人员之间的MRSA传播。
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