Loughman A, Bowden S C, D'Souza W J
Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria.
School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria.
Eur J Neurol. 2017 Mar;24(3):453-460. doi: 10.1111/ene.13232. Epub 2016 Dec 27.
Considered to be benign conditions, the common genetic generalized epilepsy (GGE) syndromes are now known to be frequently accompanied by cognitive dysfunction. However, unresolved issues impede clinical management of this common comorbidity, including which cognitive abilities are most affected, whether there are differences between syndromes and how seizure type and mood symptoms affect cognitive dysfunction. We provide a detailed description of cognitive ability and evaluate factors contributing to cognitive dysfunction.
A total of 76 adults with GGE were assessed with the Woodcock Johnson III Tests of Cognitive Abilities.
Scores on tests of overall cognitive ability, acquired knowledge, long-term retrieval and speed of information processing were significantly below the normative mean. Long-term retrieval was a pronounced weakness with a large reduction in scores (d = 0.84). GGE syndrome, seizure type and the presence of recent psychopathology symptoms were not significantly associated with cognitive function.
This study confirms previous meta-analytic findings with a prospective study, offers new insights into the cognitive comorbidity of these common epilepsy syndromes and reinforces the need for cognitive interventions in people with GGE.
常见的遗传性全身性癫痫（GGE）综合征曾被认为是良性疾病，如今已知常伴有认知功能障碍。然而，一些未解决的问题阻碍了对这种常见共病的临床管理，包括哪些认知能力受影响最大、不同综合征之间是否存在差异，以及癫痫发作类型和情绪症状如何影响认知功能障碍。我们详细描述了认知能力，并评估了导致认知功能障碍的因素。
共有76名成年GGE患者接受了伍德科克-约翰逊认知能力第三版测试。
总体认知能力、获得性知识、长期检索和信息处理速度测试的分数显著低于正常均值。长期检索是一个明显的薄弱环节，分数大幅下降（d = 0.84）。GGE综合征、癫痫发作类型和近期精神病理学症状的存在与认知功能无显著关联。
本研究以前瞻性研究证实了先前的荟萃分析结果，为这些常见癫痫综合征的认知共病提供了新见解，并强化了对GGE患者进行认知干预的必要性。
