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脊髓脑膜瘤

Spinal meningiomas.

作者信息

Hohenberger Christoph, Hau Peter, Schebesch Karl-Michael, Kölbl Oliver, Riemenschneider Markus J, Pohl Fabian, Proeschold Martin, Schmidt Nils Ole

机构信息

Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.

Brain Tumor Center, University Medical Center Regensburg, Regensburg, Germany.

出版信息

Neurooncol Adv. 2023 Jun 3;5(Suppl 1):i112-i121. doi: 10.1093/noajnl/vdad013. eCollection 2023 May.

Abstract

Spinal meningiomas (SM) are lesions with a mostly favorable oncological and surgical prognosis and a low incidence of tumor recurrence. SM account for approximately 1.2-12.7% of all meningiomas and 25% of all spinal cord tumors. Typically, SM are located in the intradural extramedullary space. SM grow slowly and spread laterally into the subarachnoid space, stretching and sometimes incorporating the surrounding arachnoid but rarely the pia. Standard treatment is surgery with the primary aims of achieving complete tumor resection as well as improving and recovering neurologic function. Radiotherapy may be considered in case of tumor recurrence, for challenging surgical cases, and for patients with higher-grade lesions (World Health Organization grade 2 or 3); however, radiotherapy is mostly used as an adjuvant therapy for SM. New molecular and genetic profiling increases the understanding of SM and may uncover additional treatment options.

摘要

脊髓脑膜瘤(SM)是一种肿瘤学和手术预后大多良好、肿瘤复发率低的病变。脊髓脑膜瘤约占所有脑膜瘤的1.2 - 12.7%,占所有脊髓肿瘤的25%。通常,脊髓脑膜瘤位于硬脊膜内髓外间隙。脊髓脑膜瘤生长缓慢,向外侧蔓延至蛛网膜下腔,牵拉并有时包绕周围蛛网膜,但很少累及软脑膜。标准治疗方法是手术,主要目的是实现肿瘤全切以及改善和恢复神经功能。对于肿瘤复发、手术难度大的病例以及高级别病变(世界卫生组织2级或3级)的患者,可考虑放疗;然而,放疗大多用作脊髓脑膜瘤的辅助治疗。新的分子和基因分析加深了对脊髓脑膜瘤的认识,并可能发现更多的治疗选择。

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