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Two predominant molecular subtypes of spinal meningioma: thoracic NF2-mutant tumors strongly associated with female sex, and cervical AKT1-mutant tumors originating ventral to the spinal cord.

作者信息

Hua Lingyang, Alkhatib Majd, Podlesek Dino, Günther Leila, Pinzer Thomas, Meinhardt Matthias, Zeugner Silke, Herold Sylvia, Cahill Daniel P, Brastianos Priscilla K, Williams Erik A, E Clark Victoria, Shankar Ganesh M, Wakimoto Hiroaki, Ren Leihao, Chen Jiawei, Gong Ye, Schackert Gabriele, Juratli Tareq A

机构信息

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Department of Neurosurgery, Carl Gustav Carus University Hospital, TU Dresden, Dresden, Germany.

出版信息

Acta Neuropathol. 2022 Nov;144(5):1053-1055. doi: 10.1007/s00401-022-02474-9. Epub 2022 Aug 9.

DOI:10.1007/s00401-022-02474-9
PMID:35943573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9547782/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/9547782/a2efec688050/401_2022_2474_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/9547782/a2efec688050/401_2022_2474_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/9547782/a2efec688050/401_2022_2474_Fig1_HTML.jpg

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Two predominant molecular subtypes of spinal meningioma: thoracic NF2-mutant tumors strongly associated with female sex, and cervical AKT1-mutant tumors originating ventral to the spinal cord.脊髓脑膜瘤的两种主要分子亚型：胸椎部NF2突变型肿瘤与女性密切相关，以及起源于脊髓腹侧的颈椎部AKT1突变型肿瘤。
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引用本文的文献

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Prevalence, natural history and surgical outcome of spinal meningiomas in NF2-related schwannomatosis.神经纤维瘤病2型相关神经鞘瘤病中脊膜瘤的患病率、自然病史及手术结果
J Neurooncol. 2025 Sep 16. doi: 10.1007/s11060-025-05231-6.
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Integrated molecular and detailed anatomical profiling identifies a prognostically adverse subtype of posterior fossa meningiomas: high-risk copy number alterations are associated with midline predilection and predict poor prognosis.整合分子和详细解剖学分析确定了后颅窝脑膜瘤的一种预后不良亚型：高危拷贝数改变与中线偏好相关并预示预后不良。
Acta Neuropathol Commun. 2025 Aug 7;13(1):168. doi: 10.1186/s40478-025-02083-z.
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Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas.
脊髓脑膜瘤中的体细胞SMARCB1突变代表了一名患有多发性散发性脑膜瘤患者的分支进化。
Neurooncol Adv. 2025 Mar 27;7(1):vdaf067. doi: 10.1093/noajnl/vdaf067. eCollection 2025 Jan-Dec.
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Clinical and molecular characteristics and long-term outcomes of pediatric intracranial meningiomas: a comprehensive analysis from a single neurosurgical center.儿童颅内脑膜瘤的临床和分子特征及长期预后：来自单一神经外科中心的综合分析
Acta Neuropathol Commun. 2025 Jan 24;13(1):15. doi: 10.1186/s40478-025-01925-0.
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Specifics of spinal neuropathology in the molecular age.分子时代脊髓神经病理学的细节
Neurooncol Adv. 2024 Feb 13;6(Suppl 3):iii3-iii12. doi: 10.1093/noajnl/vdad127. eCollection 2024 Oct.
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