García Irune, Martínez Oscar, López-Paz Juan Francisco, Salgueiro Monika, Rodríguez Alicia Aurora, Zorita Janire, García-Sanchoyerto Maddalen, Amayra Imanol
Department of Psychology, Faculty of Health Sciences, University of Deusto, Spain.
Department of Clinical and Health Psychology and Research Methodology, Faculty of Psychology, University of the Basque Country UPV/ EHU. Spain.
Intractable Rare Dis Res. 2023 May;12(2):88-96. doi: 10.5582/irdr.2023.01003.
The aim of this study was to compare the effects of the pandemic on health-related quality of life (HRQoL), anxious-depressive symptoms, feelings of loneliness, and fear of COVID-19 between people with myasthenia gravis (MG) and healthy controls. We also wanted to know in which group the variable fear of COVID-19 interfered the most with the results. This cross-sectional study involved 60 people with MG and 60 healthy controls. Participants using an online platform completed a sociodemographic questionnaire, the Short Form-36 Health Survey (SF-36), the Hospital Anxiety and Depression Scale (HADS), the revised UCLA Loneliness Scale and the Fear of COVID19 Scale (FCV- 19S). The MG group reported worse levels in HRQoL indicators ( = 0.043- <.001), more severe anxiety-depressive symptoms ( = 0.002), and greater fear of COVID-19 ( < 0.001), but there were no differences in feelings of loneliness ( = 0.002). Furthermore, after controlling for the effect of the fear of COVID-19 variable, the differences remained for physical health indicators, but not for the most of psychosocial indicators (Social Functioning = 0.102, = 0.023; Role Emotional = 0.250, = 0.011; and HADS Total = 0.161, = 0.017). The harmful effect of the COVID-19 pandemic was greater in the MG group, and the perceived fear of COVID-19 had also a greater impact among this group, which has increased its negative effect on their psychosocial health.
本研究的目的是比较重症肌无力（MG）患者与健康对照者在疫情期间健康相关生活质量（HRQoL）、焦虑抑郁症状、孤独感以及对新冠病毒的恐惧方面的差异。我们还想了解在哪个组中，对新冠病毒的恐惧这一变量对结果的干扰最大。这项横断面研究纳入了60例MG患者和60名健康对照者。参与者通过在线平台完成了一份社会人口学问卷、简短健康调查问卷36项版本（SF - 36）、医院焦虑抑郁量表（HADS）、修订后的加州大学洛杉矶分校孤独感量表以及新冠病毒恐惧量表（FCV - 19S）。MG组在HRQoL指标方面表现更差（ = 0.043 - <.001），焦虑抑郁症状更严重（ = 0.002），对新冠病毒的恐惧更强烈（ < 0.001），但在孤独感方面没有差异（ = 0.002）。此外，在控制了对新冠病毒恐惧这一变量的影响后，身体健康指标方面的差异仍然存在，但大多数心理社会指标方面的差异不再显著（社会功能 = 0.102， = 0.023；角色情绪 = 0.250， = 0.011；HADS总分 = 0.161， = 0.017）。新冠疫情对MG组的有害影响更大，并且该组中对新冠病毒的感知恐惧也产生了更大影响，这增加了疫情对他们心理社会健康的负面影响。
