Almekinders L C, Gilbert J A
Am J Sports Med. 1986 Jul-Aug;14(4):303-8. doi: 10.1177/036354658601400411.
The healing process of muscle strains and the effect of nonsteroidal antiinflammatory medication were studied using an experimental animal model. A standardized strain of the tibialis anterior muscle in adult male rats was produced by a controlled stretch of the muscle. Groups I and II underwent a unilateral strain of the tibialis anterior muscle and were immobilized in the postinjury period. The rats in Group II were fed piroxicam in the postinjury period. Group III underwent a sham procedure and were also immobilized. At 0, 2, 4, and 11 days postinjury both injured and contralateral control muscles were evaluated by determining tensile strength characteristics and histologic appearance. Group I showed a significant drop in maximum failure load to 25.7% of the control leg at Day 2 with a gradual return to the level of Group III at Days 4 and 11 (40.9% and 50.1%). Group II showed a similar drop but was still stronger than Group I at 2 days with 40.8% of the control leg and continued to drop until 4 days postinjury (33.7%). Histology showed a delay in inflammatory reaction and muscle regeneration in Group II. At 11 days both Groups I and II showed regenerated muscle fibers bridging the entire defect and an increase in endomyseal fibrosis. It is concluded that muscle strains continue to weaken in the early postinjury period. Non-steroidal antiinflammatory medication, such as piroxicam, might delay muscle regeneration.
使用实验动物模型研究了肌肉拉伤的愈合过程以及非甾体类抗炎药物的作用。通过对成年雄性大鼠的胫骨前肌进行控制性拉伸，建立了标准化的肌肉拉伤模型。第一组和第二组接受了单侧胫骨前肌拉伤，并在损伤后进行固定。第二组大鼠在损伤后给予吡罗昔康。第三组进行假手术并同样进行固定。在损伤后0、2、4和11天，通过测定拉伸强度特征和组织学外观，对受伤肌肉和对侧对照肌肉进行评估。第一组在第2天最大破坏负荷显著下降至对照腿的25.7%，在第4天和第11天逐渐恢复到第三组的水平（分别为40.9%和50.1%）。第二组表现出类似的下降，但在第2天时仍比第一组强，为对照腿的40.8%，并在损伤后4天持续下降（至33.7%）。组织学显示第二组炎症反应和肌肉再生延迟。在第11天，第一组和第二组均显示再生肌纤维跨越整个缺损，肌内膜纤维化增加。结论是，肌肉拉伤在损伤后早期会持续减弱。非甾体类抗炎药物，如吡罗昔康，可能会延迟肌肉再生。
