Obremsky W T, Seaber A V, Ribbeck B M, Garrett W E
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
Am J Sports Med. 1994 Jul-Aug;22(4):558-61. doi: 10.1177/036354659402200420.
This study was designed to observe the effect of the nonsteroidal antiinflammatory piroxicam on a controlled muscle strain injury in the rabbit model. The tibialis anterior tendons of 90 New Zealand White rabbits were detached at their distal insertions, and the right tendon was stretched to the yield point of the deformation curve. One group of 50 rabbits received piroxicam treatment and the others received no treatment. At 1, 2, 4, and 7 days the parameters of muscle function, tensile strength, and histology were examined. Muscle contractile force was significantly greater in the piroxicam-treated group at Day 1, but no difference was noted at any other time period. Tensile strength was not significantly different at any time period in either group. Histology revealed delayed degradation of damaged tissue and slowed regeneration of muscle tissue at the injury site in the piroxicam-treated group. Piroxicam and other anti-inflammatories are frequently given to athletes being treated for muscle strain injuries to control pain through their effect on the inflammatory process. This study demonstrates that piroxicam does not adversely influence the recovery of contractile and tensile strength in a followup period of 1 week. Therefore, antiinflammatory treatment may be beneficial early in the course of muscle injury.
本研究旨在观察非甾体抗炎药吡罗昔康对兔模型中可控性肌肉拉伤损伤的影响。将90只新西兰白兔的胫前肌腱在其远端附着点处切断，右侧肌腱拉伸至变形曲线的屈服点。一组50只兔子接受吡罗昔康治疗，其余兔子不接受治疗。在第1、2、4和7天检查肌肉功能、拉伸强度和组织学参数。在第1天，吡罗昔康治疗组的肌肉收缩力明显更大，但在其他任何时间段均未发现差异。两组在任何时间段的拉伸强度均无显著差异。组织学显示，吡罗昔康治疗组损伤部位受损组织的降解延迟，肌肉组织再生缓慢。吡罗昔康和其他抗炎药经常用于治疗肌肉拉伤的运动员，通过其对炎症过程的作用来控制疼痛。本研究表明，在1周的随访期内，吡罗昔康不会对收缩力和拉伸强度的恢复产生不利影响。因此，在肌肉损伤过程早期进行抗炎治疗可能有益。
