Lightowlers M W, Rickard M D, Honey R D
Am J Trop Med Hyg. 1986 Jul;35(4):818-23. doi: 10.4269/ajtmh.1986.35.818.
Production of specific serum antibodies following immunization with hydatid cyst fluid antigens was investigated in sheep with Echinococcus granulosus infection and in noninfected controls. Six of 10 infected animals responded to intramuscular injection of antigen by rapid production of antibodies detected in indirect hemagglutination assays. Similar responses did not occur in any of 10 noninfected controls. It is suggested that differences in the rate of response to immunization with cyst fluid antigens between groups of sheep could be exploited in serodiagnosis of E. granulosus infection in sheep. The results also suggest that low levels of antibody found in the serum of sheep infected with E. granulosus are not the result of immunosuppression or immunological tolerance, but are due to sequestration of antigen from the immune system of the host.
在感染细粒棘球绦虫的绵羊和未感染的对照绵羊中，研究了用包虫囊液抗原免疫后特异性血清抗体的产生情况。10只感染动物中有6只对肌肉注射抗原产生反应，通过间接血凝试验快速检测到抗体。10只未感染的对照动物中均未出现类似反应。这表明，绵羊群体之间对囊液抗原免疫反应速率的差异可用于绵羊细粒棘球绦虫感染的血清学诊断。结果还表明，感染细粒棘球绦虫的绵羊血清中发现的低水平抗体不是免疫抑制或免疫耐受的结果，而是由于抗原从宿主免疫系统中隔离所致。
