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儿童前臂远端移位骨折的肘下与肘上石膏治疗:随机对照试验的系统评价和荟萃分析

Below- versus above-elbow cast treatment of displaced distal forearm fractures in children: A systematic review and meta-analysis of randomized controlled trials.

作者信息

Alzobi Osama Z, Hantouly Ashraf T, Kenawey Mohamed, Ibrahim Talal

机构信息

Department of Orthopaedic Surgery, Hamad Medical Corporation, Doha, Qatar.

Orthopaedic Department, Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

出版信息

J Child Orthop. 2023 Jun 1;17(3):249-258. doi: 10.1177/18632521231162621. eCollection 2023 Jun.

Abstract

OBJECTIVES

Distal forearm fractures are the most common pediatric fractures. This study aimed to investigate the effectiveness of below-elbow cast treatment for displaced distal forearm fractures in children compared to above-elbow cast through meta-analysis of randomized controlled trials.

METHODS

Several databases from January 1, 2000 until October 1, 2021 were searched for randomized controlled trials that assessed below versus above-elbow cast treatment of displaced distal forearm fractures in pediatric patients. The main meta-analysis comparison was based on the relative risk of loss of fracture reduction between children undergoing below versus above-elbow cast treatment. Other outcome measures including re-manipulation and cast-related complications were also investigated.

RESULTS

Nine studies were eligible of the 156 articles identified, with a total of 1049 children. Analysis was undertaken for all included studies with a sensitivity analysis conducted for studies with high quality. In the sensitivity analysis, the relative risks of loss of fracture reduction (relative risk = 0.6, 95% confidence interval = 0.38, 0.96) and re-manipulation (relative risk = 0.3, 95% confidence interval = 0.19, 0.48) between the below and above-elbow cast groups were in favor of below-elbow cast and statistically significant. Cast-related complications were in favor of below-elbow cast but did not attain statistical significance (relative risk = 0.45, 95% confidence interval = 0.05, 3.99). Loss of fracture reduction was noted in 28.9% of patients treated with above-elbow cast and 21.5% in below-elbow cast. Re-manipulation was attempted in 48.1% versus 53.8% of children who lost fracture reduction in the below-elbow cast and above-elbow cast groups, respectively.

CONCLUSION

Below-elbow cast treatment was favored, with statistical significance, in terms of loss of fracture reduction and re-manipulation, and was not associated with a higher risk of cast-related complications. The accumulative evidence currently does not support above-elbow cast treatment and below-elbow cast treatment should be the mainstay for displaced distal forearm fractures in children.

LEVEL OF EVIDENCE

Level I, meta-analysis of therapeutic level I studies.

摘要

目的

前臂远端骨折是儿童最常见的骨折。本研究旨在通过对随机对照试验的荟萃分析,比较儿童移位型前臂远端骨折采用肘下石膏固定与肘上石膏固定治疗的有效性。

方法

检索2000年1月1日至2021年10月1日期间的多个数据库,查找评估儿童移位型前臂远端骨折采用肘下与肘上石膏固定治疗的随机对照试验。主要的荟萃分析比较基于接受肘下与肘上石膏固定治疗儿童骨折复位丢失的相对风险。还研究了其他结局指标,包括再次手法复位和与石膏相关的并发症。

结果

在检索到的156篇文章中,有9项研究符合纳入标准,共涉及1049名儿童。对所有纳入研究进行分析,并对高质量研究进行敏感性分析。在敏感性分析中,肘下与肘上石膏固定组之间骨折复位丢失的相对风险(相对风险=0.6,95%置信区间=0.38,0.96)和再次手法复位的相对风险(相对风险=0.3,95%置信区间=0.19,0.48)均支持肘下石膏固定,且具有统计学意义。与石膏相关的并发症方面,肘下石膏固定更具优势,但未达到统计学意义(相对风险=0.45,95%置信区间=0.05,3.99)。采用肘上石膏固定治疗的患者中有28.9%出现骨折复位丢失,而采用肘下石膏固定治疗的患者中这一比例为21.5%。在骨折复位丢失的儿童中,分别有48.1%和53.8%的肘下与肘上石膏固定组儿童尝试了再次手法复位。

结论

在骨折复位丢失和再次手法复位方面,肘下石膏固定治疗更具优势且具有统计学意义,并且与石膏相关并发症的风险较高无关。目前的累积证据不支持肘上石膏固定治疗,肘下石膏固定治疗应作为儿童移位型前臂远端骨折的主要治疗方法。

证据水平

I级,I级治疗性研究的荟萃分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ed/10242373/bdc642c0d984/10.1177_18632521231162621-fig1.jpg

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