Huang Xiao, Wang Bo, Yang Jing, Lian Yong-Jie, Yu Hong-Zhang, Wang Yun-Xia
Department of Nautical Psychology, Faculty of Psychology, Naval Medical University, Shanghai, 200433, China.
Department of Anaesthesiology, West China Hospital of Sichuan University, Sichuan Province, Chengdu, 610041, China.
Brain Behav Immun Health. 2023 May 25;30:100641. doi: 10.1016/j.bbih.2023.100641. eCollection 2023 Jul.
Depression is a prevalent psychiatric disorder with elusive pathogenesis. Studies have proposed that enhancement and persistence of aseptic inflammation in the central nervous system (CNS) may be closely associated with the development of depressive disorder. High mobility group box 1 (HMGB1) has obtained significant attention as an evoking and regulating factor in various inflammation-related diseases. It is a non-histone DNA-binding protein that can be released as a pro-inflammatory cytokine by glial cells and neurons in the CNS. Microglia, as the immune cell of the brain, interacts with HMGB1 and induces neuroinflammation and neurodegeneration in the CNS. Therefore, in the current review, we aim to investigate the role of microglial HMGB1 in the pathogenetic process of depression.
抑郁症是一种常见的精神疾病，其发病机制尚不明确。研究表明，中枢神经系统（CNS）中无菌性炎症的增强和持续可能与抑郁症的发生密切相关。高迁移率族蛋白B1（HMGB1）作为各种炎症相关疾病中的一种诱发和调节因子，已受到广泛关注。它是一种非组蛋白DNA结合蛋白，可被中枢神经系统中的神经胶质细胞和神经元作为促炎细胞因子释放。小胶质细胞作为大脑的免疫细胞，与HMGB1相互作用，诱导中枢神经系统中的神经炎症和神经退行性变。因此，在本综述中，我们旨在探讨小胶质细胞HMGB1在抑郁症发病过程中的作用。
