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河马通路基因中组蛋白修饰的空间分布模式研究。

Study on the spatial distribution patterns of histone modifications in Hippo pathway genes.

作者信息

Su Wenxia, Zhang Dimeng, Zhang Qiang, Li Qianzhong

机构信息

College of Science, Inner Mongolia Agriculture University, Hohhot 010018, China.

Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China.

出版信息

Biophys Rep. 2021 Feb 28;7(1):71-79. doi: 10.52601/bpr.2021.200042.

DOI:10.52601/bpr.2021.200042
PMID:37288084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10240540/
Abstract

Hippo pathway can regulate cell division, differentiation and apoptosis, and control the shape and size of organs. To study the distribution patterns of histone modifications of Hippo pathway genes in embryonic stem cells is helpful to understand the molecular regulation mechanism of histone modification and Hippo pathway on stem cell self-renewal. In this study, 19 genes of Hippo pathway including YAP, TAZ, LATS1/2, MST1 and SAV1, and eight histone modifications in embryonic stem cells were chosen to study the spatial distribution patterns of histone modifications. It was found that there were obvious type specificity and the location preference of target regions in the distributions of histone modifications, and H3K4me3 and H3K36me3 played the most important regulatory roles. Through the correlation analysis of histone modifications, a histone modification functional cluster composed of H3K4ac, H3K4me3, H3K9ac and H3K27ac was detected in YAP. In addition, the spatial distribution patterns of histone modifications in Hippo pathway genes were obtained, which provided a new theoretical reference for elucidating the mechanism of histone modifications regulating the gene expression of Hippo pathway, and for revealing the molecular regulatory mechanism of histone modifications affecting the self-renewal of embryonic stem cells by regulating the Hippo pathway.

摘要

河马通路可调节细胞分裂、分化和凋亡，并控制器官的形状和大小。研究河马通路基因在胚胎干细胞中的组蛋白修饰分布模式，有助于了解组蛋白修饰和河马通路对干细胞自我更新的分子调控机制。本研究选取了包括YAP、TAZ、LATS1/2、MST1和SAV1在内的19个河马通路基因以及胚胎干细胞中的8种组蛋白修饰，来研究组蛋白修饰的空间分布模式。研究发现，组蛋白修饰分布存在明显的类型特异性和靶区域定位偏好，且H3K4me3和H3K36me3发挥着最重要的调控作用。通过对组蛋白修饰的相关性分析，在YAP中检测到一个由H3K4ac、H3K4me3、H3K9ac和H3K27ac组成的组蛋白修饰功能簇。此外，还获得了河马通路基因中组蛋白修饰的空间分布模式，这为阐明组蛋白修饰调控河马通路基因表达的机制，以及揭示组蛋白修饰通过调控河马通路影响胚胎干细胞自我更新的分子调控机制提供了新的理论参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/75a148ce706c/br-7-1-71-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/f4ad97b8882b/br-7-1-71-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/46885f42a94a/br-7-1-71-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/68c4c75c38cb/br-7-1-71-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/25cdabfadfb8/br-7-1-71-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/75a148ce706c/br-7-1-71-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/f4ad97b8882b/br-7-1-71-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/46885f42a94a/br-7-1-71-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/68c4c75c38cb/br-7-1-71-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/25cdabfadfb8/br-7-1-71-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8a2/10240540/75a148ce706c/br-7-1-71-5.jpg

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本文引用的文献

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Front Oncol. 2019 Feb 11;9:60. doi: 10.3389/fonc.2019.00060. eCollection 2019.
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The Hippo pathway in organ development, homeostasis, and regeneration.Hippo 通路在器官发育、稳态和再生中的作用。
Curr Opin Cell Biol. 2017 Dec;49:99-107. doi: 10.1016/j.ceb.2017.12.012. Epub 2018 Jan 6.
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The Hippo pathway in tissue homeostasis and regeneration.
组织稳态与再生中的河马通路。
Protein Cell. 2017 May;8(5):349-359. doi: 10.1007/s13238-017-0371-0. Epub 2017 Jan 27.
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Gene expression classification using epigenetic features and DNA sequence composition in the human embryonic stem cell line H1.利用人类胚胎干细胞系H1中的表观遗传特征和DNA序列组成进行基因表达分类。
Gene. 2016 Oct 30;592(1):227-234. doi: 10.1016/j.gene.2016.07.059. Epub 2016 Jul 25.
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Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation.组蛋白修饰谱揭示了与人类胚胎干细胞自我更新和分化相关的差异特征。
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