Alroqi Ahmad, Abaalkhail Mashal B, Albuhayjan Nawaf, Alorainy Jehad, Jomah Mohammed, Alromaih Saud, Binkhamis Khalifa
Otolaryngology-Head & Neck Surgery, King Saud University, Riyadh, SAU.
Pathology, King Saud University, Riyadh, SAU.
Cureus. 2023 May 3;15(5):e38517. doi: 10.7759/cureus.38517. eCollection 2023 May.
Objectives This study aims to compare the severity of chronic rhinosinusitis (CRS) symptoms pre- and post-COVID-19 infection and estimate the impact of the COVID-19 pandemic on the use of intranasal corticosteroids (ICS) among adult CRS patients. Methods This was an observational retrospective cohort study conducted at King Abdulaziz University Hospital, Riyadh, Saudi Arabia, between July 2022 and October 2022. Adult CRS patients with sino-nasal outcomes test-22 (SNOT-22) scores documented prior to March 2020, marking the occurrence of Saudi Arabia's initial reported case of COVID-19, were requested to complete the SNOT-22 questionnaire following COVID-19 infection. A comparison was subsequently made between the two scores obtained. Results The study enrolled a total of 33 patients, with 16 assigned to the control group and 17 with a history of COVID-19 infection. The mean age of the patients was 43 years, and the majority (52%) were males. Statistical analysis did not reveal any statistically significant differences in the total SNOT-22 scores or domain-level scores between the two groups. Furthermore, the use of ICS during the COVID-19 pandemic did not show any significant associations, except for patients with asthma, where 80% of them used ICS during the pandemic (p=0.0073). Conclusion There was no statistically significant disparity observed in the SNOT-22 scores between patients who tested positive for COVID-19 and those who did not. The use of corticosteroids during the COVID-19 pandemic was found to be more prevalent in this study compared to previous studies conducted before the pandemic, particularly among patients with asthma. The use of ICS during the pandemic was not associated with the presence of polyps, functional endoscopic sinus surgery (FESS), allergic rhinitis, or eczema.
目的 本研究旨在比较成人慢性鼻-鼻窦炎（CRS）患者在感染新冠病毒前后CRS症状的严重程度，并评估新冠疫情对鼻内糖皮质激素（ICS）使用情况的影响。方法 这是一项于2022年7月至2022年10月在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王大学医院开展的观察性回顾性队列研究。要求2020年3月（沙特阿拉伯首次报告新冠病例之时）之前记录有鼻窦结局测试-22（SNOT-22）评分的成年CRS患者在感染新冠病毒后完成SNOT-22问卷。随后对获得的两个评分进行比较。结果 该研究共纳入33例患者，其中16例被分配至对照组，17例有新冠病毒感染史。患者的平均年龄为43岁，大多数（52%）为男性。统计分析未显示两组之间在SNOT-22总分或各领域评分上存在任何统计学显著差异。此外，在新冠疫情期间ICS的使用情况除哮喘患者外未显示任何显著关联，哮喘患者中有80%在疫情期间使用ICS（p = 0.0073）。结论 在新冠病毒检测呈阳性的患者和未检测呈阳性的患者之间，未观察到SNOT-22评分存在统计学显著差异。与疫情之前开展的既往研究相比，本研究发现新冠疫情期间糖皮质激素的使用更为普遍，尤其是在哮喘患者中。疫情期间ICS的使用与息肉的存在、功能性鼻内镜鼻窦手术（FESS）、过敏性鼻炎或湿疹无关。
