Khan Safiya Fatima, Shetty Bhavya, Fazal Ibrahim, Khan Asim Mustafa, Mir Faheem Muzaffar, Moothedath Muhamood, Reshma V J, Muhamood Muhaseena
Department of Periodontology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore - India.
Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam - Saudi Arabia.
Drug Target Insights. 2023 Jun 5;17:70-77. doi: 10.33393/dti.2023.2583. eCollection 2023 Jan-Dec.
Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice () is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of and . The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivatives in periodontal therapy. Literature review and clinical trials evaluating the effect of licorice on periodontopathogens and periodontal disease are included in this article.
牙周病是由特定病原体引起的，会导致牙齿支持结构发炎，随后导致牙槽骨和牙周韧带持续破坏。甘草是一种具有重要药用价值的多年生草本植物。甘草提取物源自甘草干燥、未去皮的匍匐茎和根。甘草提取物中的生物活性成分，如甘草酸、甘草定、光甘草定、甘草查尔酮A和甘草异黄酮A，具有抗炎、抗菌和抗黏附作用，对牙周病有益。由于牙周病的病因复杂，包括宿主反应和微生物，甘草植物化学物质因其双重功能而具有治疗优势。本综述的目的是列举草药甘草提取物中存在的生物活性化合物，并阐明甘草及其衍生物在牙周治疗中的有益作用。本文纳入了评估甘草对牙周病原体和牙周病影响的文献综述和临床试验。
