Kumar Yadav Bipin, Gupta Diksha, Kumar Thakur Rajesh, Chauhan Jatin, Mishra Rahul, Kumar Ajai
Department of Periodontology, Faculty of Dental Sciences, Uttar Pradesh University of Medical Sciences, Etawah, IND.
Department of Biochemistry, Uttar Pradesh University of Medical Sciences, Etawah, IND.
Cureus. 2025 Jan 2;17(1):e76781. doi: 10.7759/cureus.76781. eCollection 2025 Jan.
Liquorice, also known as "mulaithi" in North India, has shown anti-inflammatory, antimicrobial, and anti-adherence effects that can prevent and treat various periodontal diseases.
This study aims to assess the efficacy of subgingivally delivered liquorice gel on clinical parameters and prostaglandin E2 (PGE2) levels in chronic periodontitis.
A split-mouth, single-blind, prospective, parallel, randomized controlled clinical trial was conducted. Seventeen patients diagnosed with moderate chronic periodontitis with bilateral nearly symmetrical sites having a pocket depth of ≥4 mm but ≤6 mm were included in the study. A total of 60 sites were randomly divided into two groups, with 30 sites in each group: Group A, scaling and root planing (SRP) with subgingival delivery of liquorice gel, and Group B, SRP with subgingival delivery of placebo gel. The clinical parameters, plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and gingival crevicular fluid (GCF), samples were collected at baseline, 15th day, and 30th day after gel placement. The collected GCF samples were subjected to biochemical analysis of PGE2 levels using an ELISA kit. The Mann-Whitney U and Wilcoxon signed-rank tests were performed for intergroup and intragroup comparisons.
Statistically significant improvements in clinical and biochemical parameters were observed in both groups over time. Intergroup comparison of PI and GI showed statistically non-significant differences at all time intervals. Similarly, intergroup comparisons of PPD, CAL, and PGE2 levels showed statistically non-significant differences at baseline and 15th day. However, on the 30th day, PPD, CAL, and PGE2 levels revealed statistically significant differences between both groups. Our result corroborated that Group A, tested with liquorice gel, showed better results than Group B.
Liquorice gel can be used as an effective local drug delivery agent as an adjunct to SRP for treating chronic periodontitis.
甘草在印度北部也被称为“mulaithi”，已显示出抗炎、抗菌和抗黏附作用，可预防和治疗各种牙周疾病。
本研究旨在评估龈下递送甘草凝胶对慢性牙周炎临床参数和前列腺素E2（PGE2）水平的疗效。
进行了一项口内分侧、单盲、前瞻性、平行、随机对照临床试验。17例被诊断为中度慢性牙周炎的患者被纳入研究，其双侧部位近对称，牙周袋深度≥4mm但≤6mm。总共60个部位被随机分为两组，每组30个部位：A组，龈下递送甘草凝胶并进行龈上洁治和根面平整（SRP）；B组，龈下递送安慰剂凝胶并进行SRP。在放置凝胶后的基线、第15天和第30天收集临床参数、菌斑指数（PI）、牙龈指数（GI）、探诊牙周袋深度（PPD）、临床附着水平（CAL）和龈沟液（GCF）样本。使用酶联免疫吸附测定（ELISA）试剂盒对收集的GCF样本进行PGE2水平的生化分析。采用Mann-Whitney U检验和Wilcoxon符号秩检验进行组间和组内比较。
随着时间的推移，两组的临床和生化参数均有统计学意义的改善。PI和GI的组间比较在所有时间间隔均显示无统计学意义的差异。同样，PPD、CAL和PGE2水平的组间比较在基线和第15天显示无统计学意义的差异。然而，在第30天，PPD、CAL和PGE2水平在两组之间显示出统计学意义上显著差异。我们的结果证实，用甘草凝胶测试的A组比B组显示出更好的结果。
甘草凝胶可作为一种有效的局部给药制剂，作为SRP的辅助手段用于治疗慢性牙周炎。
