Dermatology Consulting Services, PLLC, High Point, North Carolina, USA.
Beverly Hills, California, USA.
J Cosmet Dermatol. 2023 Aug;22(8):2198-2204. doi: 10.1111/jocd.15860. Epub 2023 Jun 8.
Since 1936, injectable carboxytherapy has been used for the treatment of circulatory issues and lack of tissue trophism. In the last 25 years, it has been applied to aesthetic issues, especially those related to the signs and symptoms of skin aging. Presently, carboxytherapy is available as a combination of transcutaneous gels that produce CO with benefit for atrophic skin.
The objective of this study was to investigate the efficacy and safety of a topical carboxy mask on facial photoaging after short term use of 4 weeks and long term use of 10 weeks.
The short term study was conducted for 14 days after 3 times weekly application of the facial mask for 1 h followed by a regression phase with evaluations at days 21 and 28. 11 healthy female subjects age 45-75 years were enrolled. Subjects applied the facial mask for 45 min, 3 times per week during the 2-week treatment period. The long term study was conducted for 10 weeks on 35 subjects 35-65 years with mild to moderate facial photoaging of Fitzpatrick skin types I-VI. Subjects underwent photography, elasticity, hydration, and VAS questionnaire assessments.
The short term 4 week study demonstrated improvement in laser-Doppler measured blood flow and skin hydration. The long term 10 week study demonstrated improvement in firmness (16%, p = 0.001), sagging (9%, p = 0.023), and overall skin appearance (12%, p = 0.002). These findings were supported by the retraction time decrease at week 10 (-10%, p = 0.05).
The combination of two gels produced the liberation of CO , which improved short term skin hydration after 4 weeks of use and improved longer term skin elasticity after 10 weeks of use.
自 1936 年以来，注射用羧基疗法已被用于治疗循环问题和组织营养缺乏。在过去的 25 年中，它已被应用于美容问题，特别是与皮肤老化的迹象和症状有关的问题。目前，羧基疗法可作为一种经皮凝胶的组合，产生 CO，有益于萎缩性皮肤。
本研究旨在探讨短期使用 4 周和长期使用 10 周后，局部羧基面膜对面部光老化的疗效和安全性。
短期研究在每周 3 次应用面膜 1 小时后进行 14 天，然后在第 21 天和第 28 天进行回归期评估。纳入 11 名年龄在 45-75 岁的健康女性。受试者在 2 周治疗期间每周 3 次应用面膜 45 分钟。长期研究在 35 名年龄在 35-65 岁、皮肤类型为 I-VI 的轻度至中度面部光老化的受试者中进行了 10 周。受试者接受摄影、弹性、水分和 VAS 问卷调查评估。
短期 4 周研究显示激光多普勒测量的血流和皮肤水分改善。长期 10 周研究显示皮肤紧致度（16%，p=0.001）、下垂（9%，p=0.023）和整体皮肤外观（12%，p=0.002）改善。这些发现得到了第 10 周时回缩时间减少（-10%，p=0.05）的支持。
两种凝胶的组合产生了 CO 的释放，在使用 4 周后改善了短期皮肤水分，在使用 10 周后改善了长期皮肤弹性。
