新型面部治疗方案改善皮肤老化外观。

Novel Facial Treatment Regimen Improves Aging Skin Appearance.

出版信息

J Drugs Dermatol. 2021 Mar 1;20(3):274-278. doi: 10.36849/JDD.5791.

DOI:10.36849/JDD.5791

PMID:33683078

Abstract

BACKGROUND

Skin care regimens with multiple active ingredients offer a multimodal approach to anti-aging treatments.

OBJECTIVE

The objective of this research was to investigate the efficacy of a multimodal skincare regimen on facial skin appearance after 12 weeks of twice daily use as compared to baseline.

METHOD

35 healthy female subjects 35–65 years of age of Fitzpatrick skin types I–III with mild to moderate facial photoaging characterized by hyperpigmentation were enrolled. Subjects were seen at baseline, week 6, and week 12, and underwent subject and investigator assessments along with noninvasive evaluations (elasticity, corneometry, dermaspectrophotometer) and photography.

RESULTS

Most notable at week 12 was a 60% improvement in smoothness, 82% improvement in dryness, 30% improvement in fine lines, and 24% improvement in crow’s feet. There was an 8% reduction in macule hyperpigmentation (P<0.001) at week 12, supporting excellent pigment lightening qualities for the regimen. There was a statistically significant increase in skin firmness (decrease in elasticity) as early as week 6 of 6% with further improvement observed at week 12 of 16% (P=0.002).

SUMMARY

A multimodal skincare regimen with antioxidants, retinol, hydrolyzed pearl, caviar extract, peptides, and growth factors including EGF and TGF-β results in an improvement in the appearance of photoaged skin after 12 weeks of twice daily use. J Drugs Dermatol. 2021;20(3):274-278. doi:10.36849/JDD.5791.

摘要

背景

含有多种活性成分的护肤方案为抗衰老治疗提供了一种多模式方法。

目的

本研究旨在评估每日两次使用该多模式护肤方案 12 周后对改善面部皮肤外观的疗效，并与基线时进行比较。

方法

共纳入 35 名年龄在 35-65 岁、皮肤类型为 I-III 型（Fitzpatrick 分类）、有轻度至中度面部光老化表现（特征为色素沉着过度）的健康女性受试者。受试者分别在基线、第 6 周和第 12 周时接受评估，评估内容包括患者和研究者评估、非侵入性评估（皮肤弹性、角质层水分含量、皮肤分光光度计）和拍照。

结果

第 12 周时，皮肤光滑度显著改善 60%，皮肤干燥度显著改善 82%，细纹显著改善 30%，鱼尾纹显著改善 24%。第 12 周时斑点状色素沉着减少 8%（P<0.001），表明该方案具有出色的色素淡化效果。第 6 周时皮肤紧实度（弹性降低）即出现统计学显著增加，为 6%，第 12 周时进一步增加至 16%（P=0.002）。