ARCHE-NOAH：具有五个不同 CEST 实验的 NMR 超序列，用于研究蛋白质构象动力学。
ARCHE-NOAH: NMR supersequence with five different CEST experiments for studying protein conformational dynamics.
机构信息
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Campus Chemical Instrument Center, The Ohio State University, Columbus, Ohio 43210, USA.
出版信息
Phys Chem Chem Phys. 2023 Jun 21;25(24):16217-16221. doi: 10.1039/d3cp01580g.
An NMR NOAH-supersequence is presented consisting of five CEST experiments for studying protein backbone and side-chain dynamics by N-CEST, carbonyl-CO-CEST, aromatic-C-CEST, C-CEST, and methyl-C-CEST. The new sequence acquires the data for these experiments in a fraction of the time required for the individual experiments, saving over four days of NMR time per sample.
本文介绍了一个由五个 CEST 实验组成的 NMR NOAH 序列，可通过 N-CEST、羰基-CO-CEST、芳基-C-CEST、C-CEST 和甲基-C-CEST 研究蛋白质骨架和侧链动力学。该新序列在单个实验所需时间的一小部分时间内获取这些实验的数据，每个样品节省了超过四天的 NMR 时间。
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