运动作为一种维持端粒功能和防止细胞衰老的疗法。
Exercise as a Therapy to Maintain Telomere Function and Prevent Cellular Senescence.
机构信息
School of Kinesiology, University of Michigan, Ann Arbor, MI.
出版信息
Exerc Sport Sci Rev. 2023 Oct 1;51(4):150-160. doi: 10.1249/JES.0000000000000324. Epub 2023 Jun 7.
Abstract
Exercise transiently impacts the expression, regulation, and activity of TERT/telomerase to maintain telomeres and protect the genome from insults. By protecting the telomeres (chromosome ends) and the genome, telomerase promotes cellular survival and prevents cellular senescence. By increasing cellular resiliency, via the actions of telomerase and TERT, exercise promotes healthy aging.
摘要
运动可暂时影响 TERT/端粒酶的表达、调控和活性，以维持端粒并保护基因组免受损伤。通过保护端粒（染色体末端）和基因组，端粒酶促进细胞存活并防止细胞衰老。通过端粒酶和 TERT 的作用增加细胞的弹性，运动促进健康衰老。
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