铜催化的烯丙基醚与二氯环丁烯酮和 Bpin 的区域和立体选择性三组分偶联反应。
Copper-Catalyzed Regio- and Stereoselective Three-Component Coupling of Allenyl Ethers with -Dichlorocyclobutenones and Bpin.
机构信息
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.
出版信息
Org Lett. 2023 Jun 23;25(24):4498-4503. doi: 10.1021/acs.orglett.3c01515. Epub 2023 Jun 8.
PMID:37289963
Abstract
The three-component coupling method for regio- and stereoselective difunctionalization of allenes with allenyl ethers, bis(pinacolato)diboron, and -dichlorocyclobutenones as electrophiles was reported, yielding a variety of highly functionalized cyclobutenone products tethering with an alkenylborate fragment. The polysubstituted cyclobutenone products also underwent diverse transformations.
摘要
本文报道了三组分偶联方法，用于区域和立体选择性地对丙二烯基醚、双(频哪醇)二硼和二氯环丁烯酮等亲电试剂进行双官能化，生成了各种带有烯丙基硼酸酯片段的高官能化环丁烯酮产物。多取代的环丁烯酮产物也经历了多种转化。
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