评估视网膜电图（ERG）参数作为 ADHD 的生物标志物。
Evaluation of electroretinography (ERG) parameters as a biomarker for ADHD.
机构信息
CERVO Brain Research Centre, Centre Intégré Universitaire de Santé et des Services Sociaux de la Capitale Nationale, Quebec, QC, Canada; School of Psychology, Faculty of Social Sciences, Université Laval, Quebec, QC, Canada.
CERVO Brain Research Centre, Centre Intégré Universitaire de Santé et des Services Sociaux de la Capitale Nationale, Quebec, QC, Canada.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20;127:110807. doi: 10.1016/j.pnpbp.2023.110807. Epub 2023 Jun 7.
BACKGROUND
The retina is recognized as an accessible part of the brain due to their common embryonic origin. The electroretinogram (ERG) has proven to be a valuable tool for detecting schizophrenia and bipolarity. We therefore investigated its ability to detect ADHD.
METHODS
The cone and rod luminance response functions of the ERG were recorded in 26 ADHD subjects (17 women and 9 men) and 25 controls (16 women and 9 men).
RESULTS
No significant differences were found between the mixed groups, but sexual dysmorphia was observed in the significant results. In males, a significant prolonged cone a-wave latency was observed in the ADHD group. In females, we observed a significant decrease in the cone a- and b-wave amplitudes and a trend for a prolonged cone b-wave latency as well as a higher scotopic mixed rod-cone a-wave in the ADHD group.
CONCLUSION
The data obtained in this study show the potential of the ERG to detect ADHD, warranting further large-scale studies.
背景
视网膜由于其共同的胚胎起源而被认为是大脑的一个可及部分。视网膜电图 (ERG) 已被证明是检测精神分裂症和双相情感障碍的有用工具。因此，我们研究了它检测注意力缺陷多动障碍 (ADHD) 的能力。
方法
在 26 名 ADHD 患者（17 名女性和 9 名男性）和 25 名对照者（16 名女性和 9 名男性）中记录了 ERG 的锥体和杆体亮度反应功能。
结果
混合组之间没有发现显著差异，但在显著结果中观察到性发育异常。在男性中，ADHD 组锥体 a 波潜伏期明显延长。在女性中，我们观察到锥体 a 波和 b 波幅度显著降低，锥体 b 波潜伏期延长趋势以及暗适应混合杆锥 a 波升高。
结论
本研究获得的数据显示 ERG 有潜力检测 ADHD，值得进一步进行大规模研究。
Zotero 插件