Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
University of Düsseldorf, Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, Düsseldorf, Germany.
Nat Rev Gastroenterol Hepatol. 2023 Nov;20(11):695-707. doi: 10.1038/s41575-023-00792-1. Epub 2023 Jun 8.
A wide variety of liver functions are regulated daily by the liver circadian clock and via systemic circadian control by other organs and cells within the gastrointestinal tract as well as the microbiome and immune cells. Disruption of the circadian system, as occurs during jetlag, shift work or an unhealthy lifestyle, is implicated in several liver-related pathologies, ranging from metabolic diseases such as obesity, type 2 diabetes mellitus and nonalcoholic fatty liver disease to liver malignancies such as hepatocellular carcinoma. In this Review, we cover the molecular, cellular and organismal aspects of various liver pathologies from a circadian viewpoint, and in particular how circadian dysregulation has a role in the development and progression of these diseases. Finally, we discuss therapeutic and lifestyle interventions that carry health benefits through support of a functional circadian clock that acts in synchrony with the environment.
肝脏的多种功能受到肝脏生物钟的日常调节，并通过胃肠道内的其他器官和细胞以及微生物组和免疫细胞的系统生物钟控制。昼夜节律系统的破坏，如在倒时差、轮班工作或不健康的生活方式中发生的破坏，与几种与肝脏相关的病理有关，从代谢疾病如肥胖、2 型糖尿病和非酒精性脂肪性肝病到肝恶性肿瘤如肝细胞癌。在这篇综述中，我们从昼夜节律的角度涵盖了各种肝脏病理的分子、细胞和机体方面，特别是昼夜节律失调如何在这些疾病的发展和进展中发挥作用。最后，我们讨论了通过支持与环境同步运作的功能性生物钟来带来健康益处的治疗和生活方式干预措施。
