Department of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi, 110020, India.
Hormones (Athens). 2023 Sep;22(3):359-366. doi: 10.1007/s42000-023-00455-5. Epub 2023 Jun 8.
Hormones play a critical role in regulating various physiological processes and any hormonal imbalances can lead to major endocrine disorders. Thus, studying hormones is essential for both the therapeutics and the diagnostics of hormonal diseases. To facilitate this need, we have developed Hmrbase2, a comprehensive platform that provides extensive information on hormones.
Hmrbase2 is a web-based database which is an update of a previously published database, Hmrbase ( http://crdd.osdd.net/raghava/hmrbase/ ). We collected a large amount of information on peptide and non-peptide hormones and hormone receptors, this information being sourced from Hmrbase, HMDB, UniProt, HORDB, ENDONET, PubChem, and the medical literature.
Hmrbase2 contains a total of 12,056 entries, which is more than twice the number of entries contained in the previous version Hmrbase. These include 7406, 753, and 3897 entries for peptide hormones, non-peptide hormones, and hormone receptors, respectively, from 803 organisms compared to the 562 organisms in the previous version. The database also hosts 5662 hormone receptor pairs. The source organism, function, and subcellular location are provided for peptide hormones and receptors and properties such as melting point and water solubility is provided for non-peptide hormones. Besides browsing and keyword search, an advanced search option has also been supplied. Additionally, a similarity search module has been incorporated enabling users to run similarity searches against peptide hormone sequences using BLAST and Smith-Waterman.
To make the database accessible to various users, we designed a user-friendly, responsive website that can be easily used on smartphones, tablets, and desktop computers. The updated database version, Hmrbase2, offers improved data content compared to the previous version. Hmrbase2 is freely available at https://webs.iiitd.edu.in/raghava/hmrbase2 .
激素在调节各种生理过程中起着关键作用，任何激素失衡都可能导致主要的内分泌紊乱。因此，研究激素对于激素疾病的治疗和诊断都至关重要。为了满足这一需求，我们开发了 Hmrbase2，这是一个提供广泛激素信息的综合平台。
Hmrbase2 是一个基于网络的数据库，是之前发布的数据库 Hmrbase（http://crdd.osdd.net/raghava/hmrbase/）的更新版本。我们收集了大量关于肽和非肽激素和激素受体的信息，这些信息来源于 Hmrbase、HMDB、UniProt、HORDB、ENDONET、PubChem 和医学文献。
Hmrbase2 共包含 12056 条记录，是之前版本 Hmrbase 记录数的两倍多。这些记录包括 7406、753 和 3897 条肽激素、非肽激素和激素受体记录，分别来自 803 种生物，而之前的版本仅来自 562 种生物。该数据库还包含 5662 对激素受体。为肽激素和受体提供了来源生物、功能和亚细胞定位，为非肽激素提供了熔点和水溶性等特性。除了浏览和关键字搜索外，还提供了高级搜索选项。此外，还整合了相似性搜索模块，使用 BLAST 和 Smith-Waterman 允许用户对肽激素序列进行相似性搜索。
为了使数据库能够被各种用户使用，我们设计了一个用户友好、响应式的网站，可在智能手机、平板电脑和台式计算机上轻松使用。与之前的版本相比，更新后的数据库版本 Hmrbase2 提供了改进的数据内容。Hmrbase2 可在 https://webs.iiitd.edu.in/raghava/hmrbase2 免费获取。
