School of Life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, P. R. China.
Sci Data. 2022 Apr 25;9(1):187. doi: 10.1038/s41597-022-01287-5.
Peptide hormones (also known as hormone peptides and polypeptide hormones) are hormones composed of peptides and are signal transduction molecules produced by a class of multicellular organisms. It plays an important role in the physiological and behavioral regulation of animals and humans as well as in the growth of plants. In order to promote the research on peptide hormones, we constructed HORDB database. The database currently has a total of 6024 entries, including 5729 peptide hormones, 40 peptide drugs and 255 marketed pharmaceutical preparations information. Each entry provided comprehensive information related to the peptide, including general information, sequence, activity, structure, physical information and literature information. We also added information on IC, EC, ED, target, and whether or not the blood-brain barrier was crossed to the activity information note. In addition, HORDB integrates search and sequence analysis to facilitate user browsing and data analysis. We believe that the peptide hormones information collected by HORDB will promote the design and discovery of peptide hormones, All data are hosted and available in figshare https://doi.org/10.6084/m9.figshare.c.5522241 .
肽类激素(也称为激素肽和多肽激素)是由肽组成的激素,是一类多细胞生物产生的信号转导分子。它在动物和人类的生理和行为调节以及植物的生长中起着重要作用。为了促进肽类激素的研究,我们构建了 HORDB 数据库。该数据库目前共有 6024 条记录,包括 5729 种肽类激素、40 种肽类药物和 255 种上市药物制剂信息。每个条目都提供了与肽相关的综合信息,包括一般信息、序列、活性、结构、物理信息和文献信息。我们还在活性信息注释中添加了关于 IC、EC、ED、靶标和是否穿过血脑屏障的信息。此外,HORDB 集成了搜索和序列分析功能,方便用户浏览和数据分析。我们相信,HORDB 收集的肽类激素信息将促进肽类激素的设计和发现,所有数据都托管在 figshare 上,并可在 https://doi.org/10.6084/m9.figshare.c.5522241 获得。