Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Szigeti út 12., 7624, Pécs, Hungary.
Hungarian Nature Research Society, Ajka, Hungary.
Arch Virol. 2023 Jun 8;168(7):174. doi: 10.1007/s00705-023-05804-8.
In this study, a novel mammarenavirus (family Arenaviridae) was identified in a hedgehog (family Erinaceidae) in Hungary and genetically characterized. Mecsek Mountains virus (MEMV, OP191655, OP191656) was detected in nine (45%) out of 20 faecal specimens collected from a Northern white-breasted hedgehog (Erinaceus roumanicus). The L-segment proteins (RdRp and Z) and S-segment proteins (NP and GPC) of MEMV had 67.5%/70% and 74.6%/65.6% amino acid sequence identity, respectively, to the corresponding proteins of Alxa virus (species Mammarenavirus alashanense) identified recently in an anal swab from a three-toed jerboa (Dipus sagitta) in China. MEMV is the second known arenavirus endemic in Europe.
在这项研究中，匈牙利的一只刺猬（猬科）中发现了一种新型沙粒病毒（沙粒病毒科），并对其进行了基因特征分析。在从 20 份来自北方白刺猬（Erinaceus roumanicus）的粪便样本中，检测到了 Mecsek Mountains 病毒（MEMV，OP191655，OP191656）。MEMV 的 L 段蛋白（RdRp 和 Z）和 S 段蛋白（NP 和 GPC）与最近在中国从一只三趾跳鼠（Dipus sagitta）的肛拭子中鉴定出的阿尔山病毒（Mammarenavirus alashanense 种）的相应蛋白分别具有 67.5%/70%和 74.6%/65.6%的氨基酸序列同一性。MEMV 是在欧洲发现的第二种已知的沙粒病毒。
