Kattimani Vivekanand, Bhukya Nom Kumar Naik, Panga Gnana Sarita Kumari, Chakrabarty Abhisikta, Lingamaneni Prasanth
SIBAR Institute of Dental Sciences, Takkellapadu, Guntur, Andhra Pradesh 522509 India.
Department of Anatomy, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka 576104 India.
J Maxillofac Oral Surg. 2024 Aug;23(4):763-771. doi: 10.1007/s12663-024-02251-z. Epub 2024 Jun 21.
Nanotechnology has shown potential in treating different types of cancers. In particular, nano-drug delivery systems (DDSs) offer a promising strategy for treating oral cancer. By customizing therapy and improving drug delivery, these systems can improve outcomes for patients. Hence, a review was conducted to assess the current evidence and explore the use of DDSs for treating oral cancer.
To comprehensively explore the nano-drug carriers and target delivery for oral cancer therapy and to discuss the benefits, challenges, and potential to guide future research and clinical practice.
A systematic search of articles archived in PubMed, Scopus, and Cochrane using keywords such as Nano, drug carrier, target drug delivery, and oral cancer was performed to fulfill the objectives from inception till February 2, 2024. Articles providing insights into nano-drug carriers in oral cancer were included.
The results revealed a total of 156 articles. After duplicate removal, 136 articles were screened for title and abstract as per the inclusion and exclusion criteria. A total of 113 articles were excluded with reasons. Out of the remaining 23 articles, only 11 were included for qualitative data synthesis.
The literature revealed scarcity of oral cancer-related work using DDSs. Qualitative synthesis of data revealed that nano-drug carriers demonstrated a promising avenue for targeted therapeutic approaches in oral cancer, despite the challenges and their potential benefits. Continued research and development in this field are crucial to overcoming these challenges and fully realizing the potential of nano-drug carriers in revolutionizing oral cancer therapy.
The online version contains supplementary material available at 10.1007/s12663-024-02251-z.
纳米技术在治疗不同类型癌症方面已显示出潜力。特别是，纳米药物递送系统（DDS）为治疗口腔癌提供了一种有前景的策略。通过定制治疗方案和改善药物递送，这些系统可以改善患者的治疗效果。因此，进行了一项综述以评估当前证据，并探索DDS在治疗口腔癌中的应用。
全面探索用于口腔癌治疗的纳米药物载体和靶向递送，并讨论其益处、挑战及潜力，以指导未来的研究和临床实践。
为实现研究目标，使用“纳米”“药物载体”“靶向药物递送”和“口腔癌”等关键词，对PubMed、Scopus和Cochrane数据库中存档的文章进行了系统检索，检索时间从数据库建立至2024年2月2日。纳入了对口腔癌纳米药物载体有深入见解的文章。
结果共检索到156篇文章。去除重复文章后，根据纳入和排除标准对136篇文章的标题和摘要进行了筛选。共有113篇文章因各种原因被排除。在其余23篇文章中，仅11篇被纳入进行定性数据综合分析。
文献显示使用DDS进行的口腔癌相关研究较少。定性数据综合分析表明，尽管存在挑战，但纳米药物载体在口腔癌靶向治疗方法中显示出了一条有前景的途径及其潜在益处。该领域持续的研发对于克服这些挑战以及充分实现纳米药物载体在革新口腔癌治疗方面的潜力至关重要。
在线版本包含可在10.1007/s12663-024-02251-z获取的补充材料。
