Zhao Yue, Li Yan, Sun Lei, Gao Fang, Yin Qin, Cheng Wei, Wang Zhiping, Zeng Yinming
Xuzhou Medical University Xuzhou 221002, Jiangsu, China.
Affiliated Hospital of Xuzhou Medical University Xuzhou 221002, Jiangsu, China.
Am J Cancer Res. 2023 May 15;13(5):2201-2212. eCollection 2023.
Postoperative fatigue is prevalent, but non-small cell lung cancer (NSCLC) patients receive poor treatment after video-assisted thoracoscopic surgery (VATS). The main objective of the present trial is to observe the anti-fatigue function of pregabalin in NSCLC patients after surgery. Patients requiring VATS pneumonectomy were randomized into two groups (n=33): the experimental and control groups. The results showed that the experimental group's Identity-Consequence Fatigue Scale (ICFS) scores on days 1, 3, 7, and 30 after the operation decreased more than those of the control group. On days 1, 2, and 3 following surgery, there were significant differences in the Visual Analog Scale (VAS) scores, the incidence rate of anxiety and depression, and the Athens Insomnia Scale (AIS) scores between the two groups. Furthermore, we discovered that the ICFS scores were positively related to the VAS scores, Hospital Anxiety and Depression Scale (HADS) scores, and AIS scores. Postoperative fatigue and pain, on the other hand, were more closely related. Finally, this analysis suggested that perioperative pregabalin can reduce postoperative fatigue in NSCLC patients by relieving postoperative pain, anxiety, and depression, improving postoperative sleep quality, and promoting early recovery.
术后疲劳很常见，但非小细胞肺癌（NSCLC）患者在电视辅助胸腔镜手术（VATS）后治疗效果不佳。本试验的主要目的是观察普瑞巴林对NSCLC患者术后的抗疲劳作用。需要进行VATS肺切除术的患者被随机分为两组（n = 33）：试验组和对照组。结果显示，试验组术后第1、3、7和30天的身份-后果疲劳量表（ICFS）评分下降幅度大于对照组。术后第1、2和3天，两组之间的视觉模拟量表（VAS）评分、焦虑和抑郁发生率以及雅典失眠量表（AIS）评分存在显著差异。此外，我们发现ICFS评分与VAS评分、医院焦虑抑郁量表（HADS）评分和AIS评分呈正相关。另一方面，术后疲劳与疼痛的关系更为密切。最后，该分析表明围手术期使用普瑞巴林可通过减轻术后疼痛、焦虑和抑郁、改善术后睡眠质量以及促进早期恢复来减轻NSCLC患者的术后疲劳。
