胞外DD-肽酶的动力学参数与头孢菌素最低抑菌浓度的不相关性。
Lack of relevance of kinetic parameters for exocellular DD-peptidases to cephalosporin MICs.
作者信息
Boyd D B, Ott J L
出版信息
Antimicrob Agents Chemother. 1986 May;29(5):774-80. doi: 10.1128/AAC.29.5.774.
Abstract
MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39.
摘要
一组头孢菌素对多种革兰氏阳性和革兰氏阴性病原体的最低抑菌浓度（MIC），与这些抑制剂被链霉菌属R61菌株和马杜拉放线菌属R39菌株分泌的β-内酰胺敏感DD-肽酶酰化或去酰化的速率之间没有强相关性。
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本文引用的文献
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Substituent effects in cephalosporins as assessed by molecular orbital calculations, nuclear magnetic resonance, and kinetics.通过分子轨道计算、核磁共振和动力学评估头孢菌素中的取代基效应。
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beta-Lactam antibiotics: geometrical requirements for antibacterial activities.β-内酰胺类抗生素：抗菌活性的几何要求
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Active sites of beta-lactamases. The chromosomal beta-lactamases of Pseudomonas aeruginosa and Escherichia coli.β-内酰胺酶的活性位点。铜绿假单胞菌和大肠杆菌的染色体β-内酰胺酶。
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ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.大肠杆菌K-12的AmpC头孢菌素酶与青霉素酶型β-内酰胺酶有着不同的进化起源。
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Electronic structures of cephalosporins and penicillins. 15. Inductive effect of the 3-position side chain in cephalosporins.头孢菌素和青霉素的电子结构。15. 头孢菌素中3-位侧链的诱导效应。
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