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胞外DD-肽酶的动力学参数与头孢菌素最低抑菌浓度的不相关性。

Lack of relevance of kinetic parameters for exocellular DD-peptidases to cephalosporin MICs.

作者信息

Boyd D B, Ott J L

出版信息

Antimicrob Agents Chemother. 1986 May;29(5):774-80. doi: 10.1128/AAC.29.5.774.

DOI:10.1128/AAC.29.5.774
PMID:3729340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284153/
Abstract

MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39.

摘要

一组头孢菌素对多种革兰氏阳性和革兰氏阴性病原体的最低抑菌浓度（MIC），与这些抑制剂被链霉菌属R61菌株和马杜拉放线菌属R39菌株分泌的β-内酰胺敏感DD-肽酶酰化或去酰化的速率之间没有强相关性。

相似文献

1
Lack of relevance of kinetic parameters for exocellular DD-peptidases to cephalosporin MICs.胞外DD-肽酶的动力学参数与头孢菌素最低抑菌浓度的不相关性。
Antimicrob Agents Chemother. 1986 May;29(5):774-80. doi: 10.1128/AAC.29.5.774.
2
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Biochem J. 1976 Jun 1;155(3):623-9. doi: 10.1042/bj1550623.
3
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本文引用的文献

1
Substituent effects in cephalosporins as assessed by molecular orbital calculations, nuclear magnetic resonance, and kinetics.通过分子轨道计算、核磁共振和动力学评估头孢菌素中的取代基效应。
J Med Chem. 1983 Jul;26(7):1010-3. doi: 10.1021/jm00361a013.
2
beta-Lactam antibiotics: geometrical requirements for antibacterial activities.β-内酰胺类抗生素：抗菌活性的几何要求
J Med Chem. 1983 Feb;26(2):259-64. doi: 10.1021/jm00356a027.
3
Active sites of beta-lactamases. The chromosomal beta-lactamases of Pseudomonas aeruginosa and Escherichia coli.β-内酰胺酶的活性位点。铜绿假单胞菌和大肠杆菌的染色体β-内酰胺酶。
Biochem J. 1982 Mar 1;201(3):621-7. doi: 10.1042/bj2010621.
4
ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.大肠杆菌K-12的AmpC头孢菌素酶与青霉素酶型β-内酰胺酶有着不同的进化起源。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4897-901. doi: 10.1073/pnas.78.8.4897.
5
Electronic structures of cephalosporins and penicillins. 15. Inductive effect of the 3-position side chain in cephalosporins.头孢菌素和青霉素的电子结构。15. 头孢菌素中3-位侧链的诱导效应。
J Med Chem. 1984 Jan;27(1):63-6. doi: 10.1021/jm00367a012.
6
Des-, syn- and anti-oxyimino-delta 3-cephalosporins. Intrinsic reactivity and reaction with RTEM-2 serine beta-lactamase and D-alanyl-D-alanine-cleaving serine and Zn2+-containing peptidases.去氧、顺式和反式氧亚氨基-δ3-头孢菌素。内在反应性以及与RTEM-2丝氨酸β-内酰胺酶、D-丙氨酰-D-丙氨酸裂解丝氨酸和含锌肽酶的反应。
Biochem J. 1984 Mar 15;218(3):933-7. doi: 10.1042/bj2180933.
7
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics.细菌细胞壁肽聚糖、DD-肽酶与β-内酰胺类抗生素
Scand J Infect Dis Suppl. 1984;42:17-37.
8
Correlations between CNDO/2 charge distribution and 13C NMR chemical shift in 7-acylamino side chains of cephalosporins.
J Antibiot (Tokyo). 1984 Dec;37(12):1642-50. doi: 10.7164/antibiotics.37.1642.
9
Biosynthesis of peptidoglycan: points of attack by wall inhibitors.肽聚糖的生物合成：细胞壁抑制剂的作用靶点
Pharmacol Ther. 1984;25(3):327-69. doi: 10.1016/0163-7258(84)90004-4.
10
Penicillin-binding proteins of Streptococcus pneumoniae: characterization of tryptic peptides containing the beta-lactam-binding site.肺炎链球菌的青霉素结合蛋白：含β-内酰胺结合位点的胰蛋白酶肽段的特性分析
Eur J Biochem. 1984 Nov 2;144(3):637-41. doi: 10.1111/j.1432-1033.1984.tb08512.x.