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头孢菌素和青霉素的电子结构。15. 头孢菌素中3-位侧链的诱导效应。

Electronic structures of cephalosporins and penicillins. 15. Inductive effect of the 3-position side chain in cephalosporins.

作者信息

Boyd D B

出版信息

J Med Chem. 1984 Jan;27(1):63-6. doi: 10.1021/jm00367a012.

DOI:10.1021/jm00367a012
PMID:6690684
Abstract

Induction appears to be the primary means by which the side chain at position 3 of the cephem nucleus influences the chemical reactivity of the beta-lactam ring. In vitro antibacterial activity data suggest that when the cephalosporin is in the active site of the target bacterial enzymes, the presence of a leaving group in the side chain can promote inhibition.

摘要

诱导作用似乎是头孢烯核3位侧链影响β-内酰胺环化学反应性的主要方式。体外抗菌活性数据表明，当头孢菌素处于目标细菌酶的活性位点时，侧链中离去基团的存在可促进抑制作用。

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