阿洛西林和哌拉西林在正常成年人中的比较药代动力学。
Comparative pharmacokinetics of azlocillin and piperacillin in normal adults.
作者信息
Colaizzi P A, Polk R E, Poynor W J, Raffalovich A C, Cefali E A, Beightol L A
出版信息
Antimicrob Agents Chemother. 1986 May;29(5):938-40. doi: 10.1128/AAC.29.5.938.
Abstract
The single-dose pharmacokinetics of azlocillin and piperacillin were compared by using a randomized, crossover design. The concentrations of azlocillin in serum were consistently higher than those of piperacillin throughout an 8-h study. The area under the time-concentration curve of azlocillin was significantly greater than that of piperacillin, and the total body clearance of azlocillin was significantly lower than that of piperacillin.
摘要
采用随机交叉设计比较了阿洛西林和哌拉西林的单剂量药代动力学。在一项为期8小时的研究中，血清中阿洛西林的浓度始终高于哌拉西林。阿洛西林的时间-浓度曲线下面积显著大于哌拉西林，且阿洛西林的总体清除率显著低于哌拉西林。
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